CV Meds

Question 1

Labetalol Dose + Trade Name

Answer 1

IVP: 5mg q10min Max 20mg
Gtt: 0.05mg/kg/min

Trandate

Question 2

Labetalol MOA

Answer 2

Selective alpha 1
Nonselective beta 1,2
Beta:alpha = 7:1

Question 3

Labetalol Onset & Duration

Answer 3

O: 2-5min
D: 45min

Question 4

Esmolol Dose + Trade Name

Answer 4

IVP: 10mg q5min
Induction: 30-50mg
Gtt: 50-250mcg/kg/min

Brevibloc

Question 5

Esmolol MOA

Answer 5

Selective Beta 1 blocker

Question 6

Esmolol Onset + Duration

Answer 6

O: 1-2min
D: 10min

Question 7

Metoprolol Dose + Trade Name

Answer 7

1-5mg q5min

Blocks of 5 mg

Lopressor/Toprol

Question 8

Metoprolol MOA

Answer 8

Selective Beta 1 blocker

Question 9

Metoprolol Onset + Duration

Answer 9

O: <5min
D: 5-8hrs

Question 10

Hydralazine Dose + Trade Name

Answer 10

2.5-5mg q15min (Max 15mg)
or 0.1-0.2mg/kg

Apresoline

Question 11

Hydralazine MOA

Answer 11

Direct, Arteriolar vasodilator
GC -> cGMP
Decrease ITP and Ca release

Question 12

Hydralazine Onset + Duration

Answer 12

O: 10-20min
D: 3-6hrs

Question 13

Nitroglycerine Dose + Trade Name

Answer 13

0.2-1.5mcg/kg/min
or
5-10mcg/min

Nitrostat

Question 14

Nitroglycerine MOA

Answer 14

Venous vasodilator

NO donor -> cGMP –> inhibits calcium entry into smooth muscle and increases uptake by endoplasmic reticulum

Decrease preload

Acts on venous capacitance vessels and large coronary arteries

Question 15

Nicardipine Dose + Trade Name

Answer 15

Gtt: 5-15mg/hr

Cardene

Question 16

Nicardipine MOA

Answer 16

Dihydropyridine Ca channel blocker
Modulation of L Type VG Ca channels
Decrease calcium influx…inhibits excitation-contraction coupling

Selective for arteriolar beds

Question 17

Ephedrine Dose

Answer 17

5-10mg
Max: 150mg in 24hr

Question 18

Ephedrine MOA

Answer 18

Indirect - causes release of NE from
postganglionic sympathetic nerve endings

Alpha/Beta agonist

Question 19

Phenylephrine Dose + Trade Name

Answer 19

50-100mcg

Neosynephrine

Question 20

Phenylephrine MOA

Answer 20

Selective alpha1 agonist
A little bit: Indirect - release of NE

Concern: Reflex Bradycardia

Question 21

Vasopressin Dose

Answer 21

1-2 units
Gtt: 1-6units/hr

Question 22

Vasopressin MOA

Answer 22

ADH - acts on V1 receptor Arterial constriction

Increases H2O reabsorption kidneys (V2) via increasing renal-collecting duct permeability

Question 23

Norepi Dose

Answer 23

IVP: 5-10mcg
Gtt: 0.01-1mcg/kg/min
or 1-5mcg/kg

Question 24

Norepi MOA

Answer 24

Alpha 1 > Beta 1 > Beta 2

Question 25

Epi Dose

Answer 25

IVP: 5-10mcg
Gtt: 0.01-1mcg/kg/min
or 1-5mcg/min

Infusion for receptors
1-2 mcg/min: beta-2
4 mcg/min: beta-1
10-20 mcg/min: Predominately alpha

Question 26

Epi MOA

Answer 26

Beta 2 > Beta 1 > Alpha 2 > Alpha 1