Inhalation Agents

Question 1

Sevoflurane MAC

Answer 1

1.8

Question 2

Desflurane MAC

Answer 2

6.6

Question 3

Isoflurane MAC

Answer 3

1.17

Question 4

Nitrous Oxide MAC

Answer 4

104

Question 5

Sevoflurane B:G

Answer 5

0.69

Question 6

Isoflurane B:G

Answer 6

1.46

Question 7

Nitrous Oxide B:G

Answer 7

0.46

Question 8

Desflurane B:G

Answer 8

0.42

Question 9

Sevoflurane Vapor Pressure

Answer 9

157

Question 10

Desflurane Vapor Pressure

Answer 10

669

Question 11

Isoflurane Vapor Pressure

Answer 11

238

Question 12

Nitrous Oxide Vapor Pressure

Answer 12

Gas

Question 13

Isoflurane Pharmacodynamics

Answer 13

Halogenated methyl ethyl ether

Slower onset/offset

Degrades to CO
Decreases amplitute/increases latency of SSEPs

Question 14

Sevoflurane Pharmacodynamics

Answer 14

Fluorinated methyl isopropyl ether

Medium onset
Recovery faster than Iso

Forms Compound A (caution w/ renal pt)
Produces bronchodilation

Question 15

Desflurane Pharmacodynamics

Answer 15

Fluorinated methyl isopropyl ether

Fastest onset/offset

Pungent: Airway irriation/laryngospasm/coughing
Degrades to CO
Stimulates catecholamine release

Kinda DOC for Obese patients r/t low solubility

Question 16

Decrease MAC

Answer 16

Hypothermia
Preoperative medication, intraoperative opioids
Alpha-2 agonists
Acute alcohol ingestion
Pregnancy
Post partum (early…12-72 hours)
Lidocaine
PaO2 <38 mm Hg
Mean BP < 40mm Hg
Cardiopulmonary bypass
Hyponatremia

Question 17

Increase MAC

Answer 17

Hyperthermia

Excess pheomelanin production

Drug-induced increase in catecholamine levels

Hypernatremia

Chronic alcohol

Infants

Question 18

MH Treatment

Answer 18

Dantrolene 2.5 mg/kg IV q5-10 mins until symptoms controlled

Max 10 mg/kg

Question 19

Dantrolene MOA

Answer 19

Inhibits Calcium release from sarcoplasmic reticulum via ryanodine receptors