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Anesthesia Meds > Muscle Relaxants / Reversals > Flashcards

Muscle Relaxants / Reversals Flashcards

1
Q

Succinylcholine Dose + Concentration + Trade Name

A

Anectine

Conc: 20 mg/ml

Dose: 1 - 1.5 mg/kg

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2
Q

Cisatricurium Dose + Concentration + Trade Name

A

Nimbex

Conc: 2 mg/ml

Dose 0.1 mg/kg

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3
Q

Vecuronium Dose + Concentration + Trade Name

A

Norcuron

Conc: 1 mg/ml

Dose 0.1 mg/kg –> IDEAL BW

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4
Q

Rocuronium Dose + Concentration + Trade Name

A

Zemuron

Conc: 10 mg/ml

Dosed on IDEAL BW
Dose 0.6 mg/kg
RSI 1.2 mg/kg

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5
Q

Pancuronium Dose + Concentration + Trade Name

A

Pavulon

Conc: 2 mg/ml

Dose 0.1 mg/kg –> IDEAL BW

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6
Q

Neostigmine Dose

A

0.04 - 0.07 mg/kg
Max 5 mg

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7
Q

Sugammadex Dose + Trade Name

A

2 - 16 mg/kg

Bridion

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8
Q

Glycopyrrolate Dose + Trade Name

A

Robinul

0.2 mg per mg of Neostigmine
Max 1 mg

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9
Q

Succinylcholine MOA

A

Depolarizing neuromuscular blocking agent

Increases Na conductance via nACh
Can cause an increase in K by 0.5 mEq/dL

Cause Fasciculations

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10
Q

Non-Depolarizing NMB MOA

A

Binds at 2 nACH to prevent depolarization

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11
Q

Neostigmine MOA

A

Anticholinesterase inhibitors
Increases ACh for nACh receptors
Competetive w NDMB

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12
Q

Sugammadex MOA

A

Encapsulates steroidal NMBD
Only works for Roc, Vec, Panc
Binds to free drug in plasma

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13
Q

Glycopyrrolate MOA

A

Blocks ACh at muscarinic receptor
Blocks SLUDGE-MB (miosis,
bradycardia)

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14
Q

Succinylcholine Onset

A

30 - 60 sec

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15
Q

Succinylcholine Duration

A

5 - 10 min

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16
Q

Cisatricurium Onset

A

2 - 3 min

17
Q

Cisatricurium Duration

A

40 - 75 min

18
Q

Vecuronium Onset

A

2 - 3 min

19
Q

Vecuronium Duration

A

45 - 90 minutes

20
Q

Rocuronium Onset

A

2 - 3 mins for normal dose

1.5 min for RSI dose

21
Q

Rocuronium Duration

A

35 - 75 min per TexWes Guide

22
Q

Pancuronium Onset

A

2 - 3 min

23
Q

Pancuronium Duration

A

60 - 120 mins

24
Q

Succinylcholine Pharmacodynamics

A

Metabolism: plasma esterases

25
Q

Cisatricurium Pharmacodynamics

A

Benzylisoquinolinium

Metabolism: Hoffman Elimination

BETTER FOR LIVER & KIDNEY PATIENTS

26
Q

Vecuronium Pharmacodynamics

A

Aminosteroid

Metabolism: 20% Renal & 80% Liver/Biliary

27
Q

Rocuronium Pharmacodynamics

A

Aminosteroid

Metabolism: Unchanged in Bile 70% & Renal 30%

28
Q

Pancuronium Pharmacodynamics

A

Aminosteroid

Metabolism: 80% unchanged in urine
20% hepatic

Increased HR, MAP and CO r/t vagal blockade on SA node

29
Q

Suggamadex Onset

A

1 - 4 min

30
Q

Suggamadex Duration

A

1.5 - 3 hr

31
Q

Neostigmine Onset

A

5 - 10 min

32
Q

Neostigmine Duration

A

60 min

33
Q

Roc E 1/2 time

A

1 hr

34
Q

Vec E 1/2 time

A

1 hr

35
Q

Panc E 1/2 time:

A

2 hr

36
Q

Succinylcholine E 1/2 time

A

< 1 min

Anesthesia Meds (10 decks)

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