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Neuropharamacology > Opiods > Flashcards

Opiods Flashcards

1
Q

opioid:

A

morphine-like effects

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2
Q

opiate:

A

morphine-like structure

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3
Q

endogenous opioid peptides:

A

ekephaline
endorphins
dynorphins

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4
Q

which cells produce endogenous opioids?

A

neuronal and non-neuronal

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5
Q

opioid precursor polypeptides:

A

Preproenkephalin
Preproopiomelanocortin
Preprodynorphin

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6
Q

met and leu-enkephalins are derived from what prepro and propeptide?r

A

preproenkephalin and proenkephalin

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7
Q

Beta endorphin is derived from what prepro and pro peptide?

A

Preproopiomelanocortin
proopiomelanocortin(POMC)

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8
Q

preprodynorphin is cleaved to produce what?

A

prodynorphin

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9
Q

Golgi retention sequences are found at which stage of opiod synthesis?

A

preprohormone

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10
Q

cleaving of preprohormone is undertaken by what enzymes?

A

endopeptidases

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11
Q

which opioid receptor promotes analgesia at the spinal level?

A

kappa

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12
Q

which receptor is the target of most analgesic opioids?

A

mu

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13
Q

where do delta receptors promote analgesia?

A

periphery

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14
Q

ORL endogenous ligand:

A

nociceptin

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15
Q

describe the selectivity of beta-endorphin.

A

high, equal affinity to all 3 receptors

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16
Q

which opioids do not exhibit affinity for the kappa receptor?

A

met and leu-enkephalin

17
Q

how do the enkephalins differ in their affinity?

A

leu displays less affinity for mu

18
Q

important site of opioid action:

A

GIT
CNS
respiratory system

19
Q

analgesia components:

A

nociception and affective

20
Q

which G protein are opioid receptors coupled to?

A

Galpha i/o

21
Q

effect of opioid receptor activation on adenyl cyclase?

A

inhibit
reduce cAMP

22
Q

DAMGO

A

opioid agonist
high mu specificity

23
Q

which K+ channels do opioids activate?

A

Kir

24
Q

Which channels do opioids inhibit?

A

voltage-gated calcium channels

25
Q

which portion of GPCR binds to ion channels?

A

Beta Gamma dimer

26
Q

the direction of afferent information:

A

DRG
superior dorsal horn
thalamus
somatosensory cortex

Neuropharamacology (10 decks)

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