Anti-depressants

Question 1

amphetamine originally used to treat what kind of depression?

Answer 1

mild

Question 2

after SSRis, which anti-depressant is the most common?

Answer 2

TAC

Question 3

drugs to treat treatment-resistant depression do what?

Answer 3

enhance anti-depressant effects of drug

Question 4

anti-depressant problems

Answer 4

treatment-resistant depression, low adherence , response rates, side effects

Question 5

are anti-depressants addictive?

Answer 5

no

Question 6

how long until anti-depressant effects occur?

Answer 6

3- 6 weeks

Question 7

treatment resistant-depression treatments

Answer 7

lithium and antipsychotics

Question 8

monoamines consist of:

Answer 8

catecholamines, indolamines, histamines and trace amines

Question 9

serotonin and epinephrine broken down by which MOA?

Answer 9

MOAa

Question 10

MOAa and MOAb breakdown which neurotransmitter?

Answer 10

dopamine

Question 11

how can non-selective MOAI cause hypertensive crisis?

Answer 11

increase noradrenaline activity due to vesicular displacement
increase vasoconstriction
increases blood pressure

Question 12

which anti-depressants can cause a hypertensive crisis?

Answer 12

non-selective MOAi: Phenelzine and tranylpromine,

Question 13

first anti-depressants were?

Answer 13

MOAI

Question 14

MOAI and SSRis taken together can result in

Answer 14

serotonin syndrome

Question 15

how can MOAI cause psychosis?

Answer 15

increases DA

Question 16

when are MOAIs used?

Answer 16

when patient not responsive to other drugs

Question 17

Compare Clorgyline and Moclobemide:

Answer 17

inhibit MOAIa
clorgyline: irreversible
moclobemide: reversible

Question 18

compare the acceptability of non-selective MOAI and MOAI for MOAa

Answer 18

both as acceptable as placebo
MOAIa reduced liver and overdose toxicity and less cheese effect

Question 19

which specific MOAI induces a larger cheese effect?

Answer 19

MOA-B