Anti-depressants Flashcards
amphetamine originally used to treat what kind of depression?
mild
after SSRis, which anti-depressant is the most common?
TAC
drugs to treat treatment-resistant depression do what?
enhance anti-depressant effects of drug
anti-depressant problems
treatment-resistant depression, low adherence , response rates, side effects
are anti-depressants addictive?
no
how long until anti-depressant effects occur?
3- 6 weeks
treatment resistant-depression treatments
lithium and antipsychotics
monoamines consist of:
catecholamines, indolamines, histamines and trace amines
serotonin and epinephrine broken down by which MOA?
MOAa
MOAa and MOAb breakdown which neurotransmitter?
dopamine
how can non-selective MOAI cause hypertensive crisis?
increase noradrenaline activity due to vesicular displacement
increase vasoconstriction
increases blood pressure
which anti-depressants can cause a hypertensive crisis?
non-selective MOAi: Phenelzine and tranylpromine,
first anti-depressants were?
MOAI
MOAI and SSRis taken together can result in
serotonin syndrome
how can MOAI cause psychosis?
increases DA
when are MOAIs used?
when patient not responsive to other drugs
Compare Clorgyline and Moclobemide:
inhibit MOAIa
clorgyline: irreversible
moclobemide: reversible
compare the acceptability of non-selective MOAI and MOAI for MOAa
both as acceptable as placebo
MOAIa reduced liver and overdose toxicity and less cheese effect
which specific MOAI induces a larger cheese effect?
MOA-B
