Dementia Flashcards

1
Q

frontotemporal dementia

A

compulsive behaviours
altered eating
Picks Disease
emotion and personality disorder

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2
Q

intracellular protein aggregation in frontotemporal dementia

A

Tau , TDP-43 and FUS

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3
Q

DLB

A

lewy bodies
neurofibrillary tangles
Parkinson symptoms
fluctuating cognition
visual hallucinations
REM phase sleep disorder

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4
Q

DLB proteins

A

amyloid plaques , alpha-synuclein and tau

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5
Q

vascular dementia cause

A

mini strokes depriving neurons from oxygen and nutrients

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6
Q

vascular dementia

A

cognitive decline
thinking and reasoning impaired
memory
motor movement
mood disorder

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7
Q

Alzeheimers

A

memory and cognitive delcine
personality disorder
progression

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8
Q

proteins in Alzehimers

A

amyloid beta and tau tangles

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9
Q

acetylcholineesterase inhibitors

A

rivastigmine, galantamine and donepezil

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10
Q

what forms of dementia are cholinesterase inhibitors utilised in?

A

AL, vascular and LBD

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11
Q

added feature of galantamine

A

nicotinic receptor agonist + antiapoptipic

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12
Q

when are cholinesterase inhibitors used?

A

mod-severe

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13
Q

acetylcholinesterase adverse effects

A

GIT
psychotropic
hypertension
fainting
depression

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14
Q

contraindications of acetlylcholinesterases

A

COPD
asthma
seiures
parkinsons disease

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15
Q

relationship between TAD and acetlycholinesterase inhibitors ?

A

antagonise acetlycholineterase inhibitors

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16
Q

how does rivastigmine differ from other cholinergic esterases?

A

also binds to butylcholinesterase

17
Q

contraindications of memantine

A

epilepsy
hypertension
heart attack

18
Q

memantine mechanism of action

A

inhibits glutamate receptors