Ondansetron

Question 1

What are the indications for Ondansetron?

Answer 1

• Undifferentiated nausea and vomiting
• Prophylaxis for spinally immobilised or eye injured Pts
• Vestibular (inner ear) nausea in Pts <21y/o

Question 2

What are some contraindications for Ondansetron?

Answer 2

• Known hypersensitivity
• Concurrent Apomorphine (Parkinson’s) use
• Known Long Q-T syndrome
• Hypokalaemia or hypomagnesaemia

Question 3

What are some precautions of Ondansetron?

Answer 3

• Pts with liver disease should not receive more than 8mg/day
• Pts on diuretics who may have underlying electrolyte imbalance
• Not to be given to Pts with phenylketonuria (PKU)
• Concurrent use of Tramadol
• Pregnancy

Question 4

What are some side effects of Ondansetron?

Answer 4

• Constipation
• Headache
• Fever
• Dizziness
• Hypersensitivity reactions
• Seizures
• Visual disturbances

Question 5

What is the dosage for Ondansetron?

Answer 5

• 8mg/4mL (once only, slow push) IV

- 4mg ODT (repeat 4mg after 5-10min) Max 8mg PO

Question 6

What is the Onset, Peak and Duration of Ondansetron?

Answer 6

PO/ODT
O - 2min
P - 20min
D - 120min
IV
O - 5min
P - 10min
D - 2-6hr