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Medicine, oncology > Oncology in general > Flashcards

Oncology in general Flashcards

1
Q

What does Cytotoxins target?

A

Fast-dividing cells

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2
Q

Mab?

A

Monoclonal antibodies

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3
Q

Zu?

A

Human + mouse

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4
Q

u?

A

Human

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5
Q

xi?

A

chimeric

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6
Q

tu?

A

anti-tumor

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7
Q

lim/l/li?

A

Acts on lymphocytes

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8
Q

Which organs are affected in systemic tx (cytotoxins)?

A

Fastly replenishing organs:

  • mucosa
  • BM
  • Blood
  • Skin
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9
Q

When would anemia show after chemo?

A

100 days

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10
Q

When would neutropenia show after chemo?

A

7-10 days

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11
Q

When would thrombocytopenia show after chemo?

A

2-3 weeks

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12
Q

Most common causes of BONE metastasis?

A

LUNG
PROSTATE
BREAST

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13
Q

When could we do liver transplant?

A

ONLY if primary tumor in liver, NOT possible in metastatic disease!

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14
Q

Classical tx in colorectal ca?

A

FOLFOX

FOLFIRI

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15
Q

What is FOLFOX?

A

Oxaliplatin + 5 FU + Leucovorine

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16
Q

What is FOLFIRI?

A

Oxaliplatin + 5 FU + Irinotecan

17
Q

When do we use FOLFIRI?

A

If resistant to FOLFOX

18
Q

Which grades of side effects of a drug is ACCEPTED?

A

Grades 1 - 3 ( mild, moderate, severe)

19
Q

Cervical screening?

A

women from 25 years, every 3rd year

20
Q

Breast screening?

A

WOmen from 50 yearss

21
Q

Colorectal screening?

A

All from 50 year, every 10th year. FOBT every2nd year

22
Q

What is translational medicine?

A

Benchside + bedside + community –> promote enhancement in prevention, diagnosis and treatment

23
Q

In which animal is clinical trials done?

A

ONLY HUMANS!!!

24
Q

Phase 1 of clinical trials?

A

SAFETY and DOSE of new drug in small group of people

25
Q

Phase 2 of clinical trials?

A

Efficacy, how well does it work for given disease?

26
Q

Phase 3 of clinical trials?

A

Compare new and standard treatment, is it better?

27
Q

Phase 4 of clinical trials?

A

Report lon-term/ rare side effects

28
Q

How long time does progression from normal to cancer tissue take?

A

5-20 years

29
Q

What is tumor suppressor genes?

A

Loss of function mutation

30
Q

What is proto-oncogenes?

A

Gain of function mutations

31
Q

Indications for breast ca genetic tests?

A

BRCA1 and BRCA2 mutations in family

Early breast ca in family

32
Q

Management if BRCA1 and 2 mutations in family?

A

Preventive mastectomy and tamoxifen prophylaxis if breast cancer.

Preventive ovariectomy and oral hormonal contraceptives if ovarian cancer

33
Q

Management if FAP and ACP mutation in family?

A

Preventive colectomy

Annual colonoscopy/sigmoidoscopy

34
Q

Explain stage I of cancer?

A

Limited to organ, negative lymph nodes. 90% survival

35
Q

Explain stage II of cancer?

A

Cancer invades organ and lymph nodes. 50% survival

36
Q

Stage III of cancer?

A

locoregional advanced cancer. 20% survival

37
Q

Stage IV of cancer?

A

Metastatic cancer. 5% survival

Medicine, oncology (15 decks)

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