Antineoplastic drugs

Question 1

Which drugs are chemotherapy?

Answer 1

Cisplatin
Doxorubicin
Capecytabine

Question 2

Which drug is hormonal?

Answer 2

Tamoxifen

Question 3

Which drugs are targeted?

Answer 3

Trastuzumab
Cetuximab
Nivolumab
Bevacizumab
Imatinib
Ipilimumab
Vemurafenib

Question 4

Which drugs are cardiotoxic?

Answer 4

Doxorubicin

Traztuzumab

Question 5

Which drugs are nephrotoxic?

Answer 5

Cisplatin

Question 6

Which side effects does Cisplatin have?

Answer 6

Nephrotoxicity
N/V
Neurotoxicity
Ototoxicity
BM suppression

Question 7

Side effects of capecytapine?

Answer 7

BM suppression
GI symptoms
HAND FOOT syndrome

Question 8

How is capecytapine adm?

Answer 8

Orally

Question 9

When is capecytapine used?

Answer 9

Colorectal and breast cancer

Question 10

Side effects of Doxorubicin?

Answer 10

CARDIOTOXICITY

• early (arrhythmias
• late (congestive HF)

Question 11

Which drug has side effects affecting vessels?

Answer 11

Bavacizumab

Question 12

Mechanism of Tamoxifen?

Answer 12

Anti-estrogen

Question 13

When is tamoxifen used?

Answer 13

Breast ca

Question 14

Administration of Tamoxifen?

Answer 14

Oral

Question 15

Side effects of tamoxifen?

Answer 15

Endometrial cancer

Menopausal symptoms

Question 16

Which drug has red discoloration of urine?

Answer 16

Doxorubicin

Question 17

How long is adjuvant treatment with trastuzumab?

Answer 17

1 year

Question 18

Another name for trastuzumab?

Answer 18

Herceptin

Question 19

Mechanism of trastuzumab?

Answer 19

Anti-HER2

Question 20

When is trastuzumab used?

Answer 20

Breast and gastric ca

Question 21

Side effect of trastuzumab?

Answer 21

Cardiotoxicity

Question 22

When is cetuximab used?

Answer 22

Colorectal and H/N cancer

Question 23

Mechanism of cetuximab?

Answer 23

Binds to EGFR

• -> inhibits cell growth
• -> induce apoptosis

Question 24

When is cetuximab ineffective?

Answer 24

If present K-ras mutation

Question 25

SIde effects of cetuximab?

Answer 25

Skin toxicity = acne like rash

Question 26

What disease is Nivolumab tx for?

Answer 26

Melanoma

Question 27

Which drugs can be used in melanoma?

Answer 27

Nivolumab Ipilimumab Vemurafenib

Question 28

What does nivolumab act on?

Answer 28

Lymphocytes

Question 29

Mechanism of nivolumab?

Answer 29

Anti-PD1 --> inhibits programmed death

Question 30

Side effect of nivolumab?

Answer 30

Autoimmune reactions (CRAZY lymphocytes)

Question 31

When is bevacizumab used?

Answer 31

Colorectal ca, ovarian ca

Question 32

Mechanism of bevacizumab?

Answer 32

Anti-VEGF

Question 33

Side effects of bevacizumab?

Answer 33

HTN Hemorrhage Thromboembolism

Question 34

Which stage of colorectal ca is bevacizumab used in?

Answer 34

Stage IV

Question 35

Mechanism of Imatinib?

Answer 35

Tyrosine-kinase inhibitor

Question 36

Administratoin of Imatinib?

Answer 36

Oral

Question 37

When is Imatinib used?

Answer 37

CML, GIST

Question 38

Side effects of Imatinib?

Answer 38

WELL tolerated

Question 39

Ipilimumab mechanism?

Answer 39

CTLA 4-inhibitor = activates T cell

Question 40

When is Ipilimumab used?

Answer 40

Melanoma

Question 41

Side effects of ipilimumab?

Answer 41

Autoimmune reaction

Question 42

Mechanism of Vemurafenib?

Answer 42

BRAF kinase inhibitor

Question 43

Usage of Vemurafenib?

Answer 43

Melanoma

Question 44

Side effect of vemurafenib?

Answer 44

Skin toxicity