Metastatic melanoma Flashcards
1
Q
What diagnostic test?
A
FULL thickness excisional biopsy!
2
Q
What are safety margins for melanoma?
A
Early stage (I and II): 1 cm Late stage (III and IV): 2 cm
3
Q
MOST important prognostic factor?
A
Thickness
4
Q
How to classify thickness?
A
Breslow scale
5
Q
Common metastases?
A
Skin Lymphoma Lung Brain Liver Bones
6
Q
MC cytotoxic drug?
A
Dacarbazine
7
Q
Side effects of dacarbazine?
A
N/V, leukopeniam thrombocytopenia, anemia
8
Q
Modern drugs?
A
Ipilimumab
Nivolumab
Vemurafenib
Trametinib
9
Q
Mechanism of ipilimumab?
A
CTLA-4 inhibitor = activates T cells
10
Q
Side effect of Ipilimumab?
A
Skin toxicity (rash) \+ severe adverse reactions
11
Q
Mechanism of nevolumab?
A
PD-1 inhibitor = blocks program death
12
Q
Side effect of nevolumab?
A
Skin toxicity
13
Q
Mechanism of Vemurafenib?
A
BRAF inhibitors
14
Q
Sideeffects of Vemurafenib?
A
Skin toxicity
15
Q
Mechanism of Trametinib?
A
MEK inhibitor
