Oncology Flashcards
BCR-ABL
oncogene
CML, ALL
tyrosine kinase, Philadelphia chromosome
bcl-2
oncogene
follicular and undifferentiated lymphomas
anti-apoptotic molecule
BRAF
oncogene
melanoma
serine/threonine kinase
c-kit
oncogene gastrointestinal stromal tumor (GIST) cytokine receptor (for stem cell factor)
c-myc
oncogene
Burkitt lymphoma
transcription factor
HER2/neu (c-erbB2)
oncogene
breast, ovarian, gastric carcinoma
tyrosine kinase
L-myc
oncogene
lung tumor
transcription factor
N-myc
oncogene
neuroblastoma
transcription factor
ras
oncogene
colon cancer, lung cancer, pancreatic cancer
GTPase
ret
oncogene
MEN 2A and 2B
tyrosine kinase
APC
tumor suppressor
colorectal cancer
BRCA1
tumor suppressor
breast and ovarian cancer
DNA repair protein
BRCA-2
tumor suppressor
breast and ovarian cancer
DNA repair protein
CPD4/SMAD4
tumor suppressor
pancreatic cancer
DPC
DCC
tumor suppressor
colon cancer
DCC
MEN1
tumor suppressor
MEN type 1
NF1
tumor suppressor
neurofibromatosis type 1
RAS GTPase activating protein (neurofibromin)
NF2
tumor suppressor
neurofibromatosis type 2
Merlin (schwannomin) protein
p16
tumor suppressor
melanoma
cyclin-dependent kinase inhibitor 2A
p53
tumor suppressor
most human cancers, Li-Fraumeni syndrome
transcription factor for p21, blocks G1–> S phase
PTEN
tumor suppressor
breast cancer, prostate cancer, endometrial cancer
Rb
tumor suppressor
retinoblastoma, osteosarcoma
inhibits E2F; blocks G1–> S phase
TSC1
tumor suppressor
tuberous sclerosis
hamartin protein
TSC2
tumor suppressor
tuberous sclerosis
tuberin protein
VHL
tumor suppressor
von Hippel-Lindau disease
inhibits hypoxia inducible factor 1a
WT1
tumor suppressor Wilms Tumor (nephroblastoma)
WT2
tumor suppressor Wilms tumor (nephroblastoma)
t(9;22)
Philadelphia chromosome
CML
bcr-abl hybrid
t(8;14)
Burkitt lymphoma
c-myc activation
t(11;14)
Mantle cell lymphoma
cyclin D1 activation
t(14;18)
Follicular lymphomas
bcl-2 activation
t(15;17)
M3 type of AML
responsive to all-trans retinoic acid
