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Board Review > Oncology > Flashcards

Oncology Flashcards

1
Q

BCR-ABL

A

oncogene
CML, ALL
tyrosine kinase, Philadelphia chromosome

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2
Q

bcl-2

A

oncogene
follicular and undifferentiated lymphomas
anti-apoptotic molecule

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3
Q

BRAF

A

oncogene
melanoma
serine/threonine kinase

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4
Q

c-kit

A 
oncogene
gastrointestinal stromal tumor (GIST)
cytokine receptor (for stem cell factor)
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5
Q

c-myc

A

oncogene
Burkitt lymphoma
transcription factor

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6
Q

HER2/neu (c-erbB2)

A

oncogene
breast, ovarian, gastric carcinoma
tyrosine kinase

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7
Q

L-myc

A

oncogene
lung tumor
transcription factor

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8
Q

N-myc

A

oncogene
neuroblastoma
transcription factor

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9
Q

ras

A

oncogene
colon cancer, lung cancer, pancreatic cancer
GTPase

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10
Q

ret

A

oncogene
MEN 2A and 2B
tyrosine kinase

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11
Q

APC

A

tumor suppressor

colorectal cancer

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12
Q

BRCA1

A

tumor suppressor
breast and ovarian cancer
DNA repair protein

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13
Q

BRCA-2

A

tumor suppressor
breast and ovarian cancer
DNA repair protein

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14
Q

CPD4/SMAD4

A

tumor suppressor
pancreatic cancer
DPC

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15
Q

DCC

A

tumor suppressor
colon cancer
DCC

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16
Q

MEN1

A

tumor suppressor

MEN type 1

17
Q

NF1

A

tumor suppressor
neurofibromatosis type 1
RAS GTPase activating protein (neurofibromin)

18
Q

NF2

A

tumor suppressor
neurofibromatosis type 2
Merlin (schwannomin) protein

19
Q

p16

A

tumor suppressor
melanoma
cyclin-dependent kinase inhibitor 2A

20
Q

p53

A

tumor suppressor
most human cancers, Li-Fraumeni syndrome
transcription factor for p21, blocks G1–> S phase

21
Q

PTEN

A

tumor suppressor

breast cancer, prostate cancer, endometrial cancer

22
Q

Rb

A

tumor suppressor
retinoblastoma, osteosarcoma
inhibits E2F; blocks G1–> S phase

23
Q

TSC1

A

tumor suppressor
tuberous sclerosis
hamartin protein

24
Q

TSC2

A

tumor suppressor
tuberous sclerosis
tuberin protein

25
Q

VHL

A

tumor suppressor
von Hippel-Lindau disease
inhibits hypoxia inducible factor 1a

26
Q

WT1

A 
tumor suppressor
Wilms Tumor (nephroblastoma)
27
Q

WT2

A 
tumor suppressor
Wilms tumor (nephroblastoma)
28
Q

t(9;22)

A

Philadelphia chromosome
CML
bcr-abl hybrid

29
Q

t(8;14)

A

Burkitt lymphoma

c-myc activation

30
Q

t(11;14)

A

Mantle cell lymphoma

cyclin D1 activation

31
Q

t(14;18)

A

Follicular lymphomas

bcl-2 activation

32
Q

t(15;17)

A

M3 type of AML

responsive to all-trans retinoic acid

Board Review (11 decks)

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