Oncology Flashcards
1
Q
Antimetabolites S/E
A
N/V Diarrhea Bone marrow suppression Stomitis Renal Toxicity (methotrexate) Hepatotoxicity
2
Q
Antimetabolites end in
A
-bine (capecitabine, azacytedine) methotrexate
3
Q
Action of Antimetabolites
A
Halts the synthesis of cell protein (DNA, RNA) and impairs cell devision. (S cycle specific)
4
Q
Mitotic end in
A
-stine, -axel ( Vinblastine, paclitaxel)
5
Q
Action of Mitotic
A
M cycle specific. Arrest metaphase by inhibiting mitotic tubular formation (spindle), inhibit DNA and protein synthesis.
6
Q
Mitotic S/E
A
Bone marrow suppression Hypersensitivity reaction Peripheral neuropathies N/V alopecia
7
Q
Topoisomerase I &II inhibitor end in
A
-can, -side (Irinotecan, Etoposide)
8
Q
Topoisomerase I &II inhibitor action
A
S cycle specific. Induce break in DNA strand by binding to enzyme topoisomerase, preventing cells from dividing
9
Q
Topoisomerase I &II inhibitor
A
N/V diarrhea flulike symptoms rash Bone marrow suppression Hepatotoxicity
