Oncology Flashcards
What is the tumor free percentage of animals with cutaneous MCT treated with tigilanol tiglate (Stelfonta). When are reccurances most likely to occur?
89%
Most likely to occur within 3 months.
https://paperpile.com/app/p/7c8e49ee-5e19-0bfd-9829-08b8832f64ca
What is the distribution of where treatment failures occur for dogs treated with radiation therapy for Sino-nasal tumors?
75% occur within the field of treatment.
19% occur in the marginal area
6% occur out of field
https://paperpile.com/app/p/ec27b91f-9dec-06e9-acc3-e33180baadcc
What types of dogs are predisposed to B-cell CLL?
Small breed dogs and:
English Bulldogs who may have their own phenotype (younger 6 years, with lower MHC II and CD25 expression).
https://paperpile.com/app/p/91e9503e-ad76-0a21-a84d-8780094bb6d0
What percentage of dogs with B-CLL will have peripheral lymphadenopathy or splenomegaly?
50%
Nb. 26% will be anaemic.
https://paperpile.com/app/p/91e9503e-ad76-0a21-a84d-8780094bb6d0
What is p53 and its role in prognosis of dogs with high grade lymphoma?
p53 is a protein that induces apoptosis in health therefore tumour cells can become apoptosis resistent if this is muated.
- 16% dogs had p53 mutation
- Mutation assoc. with lower response rates after remission induction (33% vs. 88%)
- Shorter OST in p53 mutation dogs (67 vs. 264 days)
https://paperpile.com/app/p/b9022925-30b7-0a64-95f1-a56e8eda1856
In what circumstances is OHE likely to be beneficial in preventing recurrance of mammary carcinomas in dogs?
OHE was not significantly associated with reduced chance of relapse overall until looking at subgroups. It was beneficial if:
- Dogs had higher estradiol (E2)
- Tumours were grade 2
- Tumours expressed eostrogen receptor
https://paperpile.com/app/p/24249ed4-d391-089e-b1b3-22786c00aa35
What percentage of dogs become neutropenic following lomustine administration with the FDA approved product?
71%
https://paperpile.com/app/p/78bc0634-70c4-0993-aece-c724a5ffa35a
What is the relationship between lomustine concentrations in compounded formulations in the USA and their label concentration?
only 1 sample was within 10% of the label concentration with the remainder having concentrations ranging between 50 - 115% of their label concentrations
What is the relationship between the anti-apoptotic molecule Bcl-2 and proapoptitic molecule Bax in canine lymphoma type and survival?
Higher ratio in TCL but no significant impact on survival noted.
https://paperpile.com/app/p/df9de8d4-61d8-0daa-aec2-c46771d9acc8
MST of canine brain tumours following SRT?
364 days
What percentage of dogs treated with toceranib become hypertensive?
37%
https://paperpile.com/app/p/79ed7604-51c7-0d33-a2ff-9369e8cf24ee
Which neoplasias is the neoplasia index most likely to be increased in?
Lymphoma and histocytic sarcoma
https://paperpile.com/app/p/4d76fa68-ea2c-0229-a1fe-0e09770bfa1a
What are the proven effects of monocyte function and phenotype in dogs with osteosarcoma?
CR2 and CXCR2 expression were lower in dogs with OSA compared to controls
- PGE2 and TNFa levels were higher in monocyte cutlures of dogs with OSA
- OSA dogs had monocytes with decreased chemotactic function
https://paperpile.com/app/p/a77622d8-aa0b-01ec-bb60-e5d22eb12bf8
What impact does body condition have on dogs with lymphoma or osteosarcoma?
a) Overweight at diagnosis associated with decreased survival time for both
b) Underweight at diagnosis associated with decreased survival time for both
c) Underweight associated with decreased survival time and PFI in dogs with LSA
d) Underweight associated with decreased survival time only in dogs with LSA
D
https://paperpile.com/app/p/a0fe5c33-544a-08b4-9740-7e01c7143daa
What is the impact of zolundrunate on the expression of CXCR4 in canine OSA?
- Zolendrunate ecreased CXCR4 expression and functionality by 27.7% in 33% of cell lines evaluated
- Decreased CXCR expression in primary tumours by 33%
- Reduced circulating CXCR in 18/20 dogs with OSA
https://paperpile.com/app/p/529e49a9-75e7-063d-8847-0ac28c849f1a
Risk factors for development of HS in Burnese mountain dogs
Diagnosis of an orthopaedic condition was a risk factor for development of HS
Dogs receiving prescription NSAIDS were at lower risk for development of HS
https://paperpile.com/app/p/818783de-c27a-07d1-a6f8-2c6942de35b3
Relationship of the use of CT vs. AUS for detection of AGASACA metastasis in local Las?
CT likely to detect more sites of metastasis but AUS will detect at least 1 site, so essentially CT is probably better for surgical planning etc. but if the aim is just to document the presence of metastasis then AUS is fine.
https://paperpile.com/app/p/bf452ac5-806b-0729-a2c9-95db483d43ac
Diagnostic asccuracy of cytology and histopathology in diagnosis of canine bone lesions
- Cytology was 83% accurate (sensitvity 83.3% and specificity 80%)
- histology was 82.1% accurate (sensitivity sensitivity 72.2% and specificity 100%)
- Tumour type correctly identified in only50% cases
- No cytologically malignant tuours were diagnosed in error
https://paperpile.com/app/p/bdc19241-2b76-054e-ad59-5ef0c3f4cc29
Response rate and PFI for rabacfosadine/doxorubicine for naive canine multicentric lymphoma?
Comparable to other protocols:
- Overall response rate 84%
- PFI 194 days (6 months)
https://paperpile.com/app/p/8b8800e9-c949-0281-8653-eed311c9b731
Cutaneous plasmacytosis breeds, treatment responses and PFI/MST
- Most common breeds were golden (5/21) and labrador (3/21) retrievers
- Prednisolone and melphalan gave a RR of 73.7%, lomustine RR was 71.4%
- MPFI was 153 days and MST was 542 days
https://paperpile.com/app/p/94423d66-ea51-0b4e-81cc-a8ff8fd2a45c
MST of canine SI adenocarcinoma treated surgically? What age is associated with a better prognosis?
544 days, age <8 years
What size of AGASACA is liklely to have a facourable survival time with surgery alone in early stage disease?
<3.2cm has an MST of 1,237 days
What is the most common response of dogs with AGASACA to toceranib?
Stable disease - achieved in around 50%
What is the most common presentation of cats with AGASACA?
Perineal ulceration and discharge
What breed is predisposed to a non-neoplastic B-cell lymphocytosis and what testing could be performed to determine if malignant?
English bulldogs with about 70% of these having a non-malignant process.
Detect by demonstration of CD21+ lymphocytes and IgG gene rearrangement which is polyclonal
Which breed of dog has a shorter survival time in b-cell CLL?
Boxers
What are the prognostic factors for canine BCLL?
Ki-67 >40%, lymphocyte count > 60 and the presence of clinical signs at presentation
What JAK/STAT gene has been shown to be upregulated in canine lymphoma?
STAT3 and ERK1/1. The former is associated wiht survival
What abnormality of lymphoid organs are Golden Retrievers known for?
T-zone like cells are prominent in older golden retrievers