Gastrointestinal Flashcards
Does faecal culture identify faecal dysbiosis?
No
https://paperpile.com/app/p/ec231630-e39d-0a6d-a1c4-a612523b6bf7
What is the OR for dogs with PLE receiving assisted enteral feeding when treated with dietary and immunosuppressive treatment for a positive outcome?
OR = 7 in this group.
N.b. dogs that had dietary treatment alone had an OR of 36.1 when managed with diet alone. Bear in mind that this could reflect animals that had less severe disease process, however.
https://paperpile.com/app/p/7495b163-d412-0ca1-bfbd-29c6ecdf1404
What dose of oral cobalamin has been shown to be effective at increasing cobalamin concentrations in dogs, what duration of follow up did this occur over?
250mcg/10kg, follow up was 20 - 202 days in a retrospective study that looked at this. Mean increase was 794ng/mL
https://paperpile.com/app/p/4ce4bab2-a67d-0c2b-99a3-66b6735ca93c
Which fluoroquinolone has been shown to have reduced oral bioavailability when given with sucralfate? Which one was not affected? How can the affect on oral bioavailability be improved?
Ciprofloxacin was affected whilst enrofloxacin was not. Oral bioavailability of ciprofloxacin improved when sucralfate was given 2 hours after ciprofloxacin.
https://paperpile.com/app/p/7839af5a-66d2-04b8-aaa3-a4697129c9f7
What liver enzyme elevation is associated with increased duration of hospitalisation in canine acute pancreatitis?
ALT
https://paperpile.com/app/p/e31cb18d-acd7-02cc-bb1c-73a5563baab1
What percentages of the following was found in a study of the cytologic findings of canine and feline bile aspirates?
a. Infectious agents
b. inflammation
c. cytologic identification of infection vs. culture
30% canine, 22% feline
5% canine, 19% feline
24% for cytology and 21% for culture
https://paperpile.com/app/p/63b4464f-898d-0850-a7ef-8c28c84d273f
What are the most common organisms identified on bile culture?
E. coli (14.8%) and Enterococcus (6.7%)
https://paperpile.com/app/p/63b4464f-898d-0850-a7ef-8c28c84d273f
What clfinicopathologic variable is associated with the presence of micro-organisms on canine bile aspirates?
Increased cPLI
https://paperpile.com/app/p/63b4464f-898d-0850-a7ef-8c28c84d273f
What is intestinal leiomyositis, what are the presenting signs and prognois?
Autoimmune inflammation of the lamina propria of the GIT, casues an acute presentation of intestinal pseudo-obstruction. It has a poor prognosis in the small case series presented (MST 19 days)
https://paperpile.com/app/p/4b9fc22c-d2a4-01ae-96d6-770f2abe5146
What is the potential prevalence of biliary sludge in healthy dogs?
58%
https://paperpile.com/app/p/f8e3b5db-f520-0973-8317-6e937bd2893e
What is the effect of omeprazole on serum gastrin in cats? What happens to stomach acidity following discontinuation of therapy?
Only variable that was affected was serum gastrin that was significantly increased during omeprazole treatment. Hyperacifity was also noted in cats folowing cessation of omeprazole treatment.
n.b. calcium, Mg, cobalamin, Mg were all unaffected.
https://paperpile.com/app/p/d741b251-c981-0277-9773-ff0900bc25ca
Which diagnostic test is more liekly to detect platynosomum eggs in cats?
Cholecystocentesis is superior to faecal egg counts in the number of eggs detected.
https://paperpile.com/app/p/2d7c8031-a90d-0d8c-b2e4-99d7ac65ed8e
What bacterial organism should be considered if neutrophilic enteropathy is noted in a cat that has gastrointestinal biopsies?
Campylobacter coli
https://paperpile.com/app/p/25d62d04-45cc-0f64-8248-b60f11ad848c
How many times can reusable endoscopy forceps be used without affecting the quality of biopsy samples?
At least 10x
https://paperpile.com/app/p/fa6c0c3a-bf85-033c-aa53-e2c105b5f57d
What is the relationship between complication rate/severity in dogs that have a PEG tube placement who are or are not receiving corticosteroids?
Similar complication rate but severe complications more frequent in steroid-treated group
https://paperpile.com/app/p/22e16935-38b2-078c-8524-cc05747695b6
What handling method of endoscopic biopsy samples may be best?
USe of a synthetic sponge, this gave less artifacts and histopathology that was more definitive than samples prepared on a cucumber slice or floating in formalin.
https://paperpile.com/app/p/0ccfebc8-feca-0e22-8395-be115690b7e5
What is the most common other organ affected with IBD in feline triaditis?
Cholangitis or all three, pancreatitis + IBD is much less common
https://paperpile.com/app/p/e3fb5a0d-213b-069e-b39b-50a0b5b01b0a
Most common bacterial isolates in canine cholangitis
E.coli > Enterococcus > Clostridium
https://paperpile.com/app/p/0f83f7e3-c748-06e2-84a0-26bad8db181c
Incidence of biliary tract rupture in canine cholangitis/cholexystitis?
1/3 cases
https://paperpile.com/app/p/0f83f7e3-c748-06e2-84a0-26bad8db181c
What factors seem to be predictive of a good response to treatment in cats with EPI?
- TLI <4ug/l
- Cobalamin supplementation
https://paperpile.com/app/p/f02e1080-2c06-05fa-b598-9952297caf87
Which of the following is associated with increased leptin concentrations in dogs with GB mucocoele
a. Having HAC
b. Having DM
c. Having surgical treatment vs. mnedical
d. Leptin actually lower in GB mucocoele compared to healthy controls
c
https://paperpile.com/app/p/4e5fbbb2-b051-0c30-8a62-01b496f5914a
Feasibility of 99mTc labelled human albumin for diagnosis of PLE in dogs?
- 7 dogs had 99mTc labelled human serum albumin injected and compared to healthy dogs
- 1 control dog had exudation into the GI tract
- all 7 dogs with PLE had Tc labelled albumin ecudation into the gut
- 5 dogs had Tc exudation into the GI tract that was not disputed (2 docal and 3 diffuse)
- 2 dogs had disagreement as to whether it was focal or diffuse
https://paperpile.com/app/p/56c7b662-7e5e-06e6-8b31-cd7baa989af2
Intestinal histopathology findings that have increased frequency in dogs with PLE (albumin <30g/L)
- Higher WSAVA scores
- Villous stunting
- Epithelial injury
- Crypt distension
- Lacteal dilation
- Intraepithelial lymphocytes
- Neutrophils in lamina propria
https://paperpile.com/app/p/da328fc4-4dad-01a0-acf9-a93e9156f672
Effect of synbiotic supplementation wiht E. faecium, FOS and acacia in sheltered dogs on the incidence of diarrhoea?
- Mean percentage ofdays with diarrhoea was less in the synbiotic group (2%) compared to 3.2% in the placebo group
- Occurance of diarrhoea within first 14 days was lower in synbiotic group (18.*%) compared to placebo group (27.2%).
- Occurance of >2 consecutive days of diarrhoe was lower in the synbiotic group (4.6%) compared to 8% in the placebo group
https://paperpile.com/app/p/c8054666-2ecf-0039-8941-b7d04cd305e6
Does age have any impact on changes in swallow metrics in dogs evaluated with videofluroscopy?
No
https://paperpile.com/app/p/93ab4725-3e56-0d40-a4f1-f272f340efa0
Gastric emptying time in cats
- Ultrasonography was correlated to schintigraphic gastric emptying times in cats
- 25% GET was approx. 2 hours
- 50% GET was approx 3 - 4 hours
- 75% GET was approxx 5 - 6 hours
https://paperpile.com/app/p/6eacc625-a931-0c31-bdbf-27995b881fb2
Prevalence of GER in cats that have GA
33.%
https://paperpile.com/app/p/c4e0de3f-053c-0e71-b3dc-b57701488325
Effect of two does of omeprazole in cats on serum gastrin measurement?
None
https://paperpile.com/app/p/c4e0de3f-053c-0e71-b3dc-b57701488325
What is the order in which administration routes of esomeprazole gives the longest MPT for increased gastric pH?
PO > SQT > IV
Possibly this is to do with the T1/2 with these administration routes??
https://paperpile.com/app/p/d374ed86-a3ee-02a9-9d8f-8ae59aec0d2e
Percentage of dogs with chronic diarrhoea that have primary enteropathy compared to secondary causes.
- 90% dogs with chronic diarrhoea have primary enteropathy (71% inflammatory, 13% infectious, 4% neoplastic)
- 10% had secondary causes (exocrine pancreatic 6%, endocrine (2%) and one each in hepatic, renal and cardiac disease)
https://paperpile.com/app/p/371dd0a3-6da6-0979-8930-930af5f92004
Serum 3-bromotyrosine conentrations in dogs with chronic enteropathy (SRE vs. FRE)
3-BrY was higher in dogs with SRe compared to FRE and healthy dogs
Peripheral eosinophil counts were not useful, 3-BrY di not correlate to CCEAI
https://paperpile.com/app/p/0d06e443-3820-03e5-a5fb-36191aac1306
Taurine concentrations in cats with diarrhoea?
- Cats with large intestinal diarrhoa hd lower taurine than cats with small intestinal diarrhoea and mixed intestinal diarrhoea
https://paperpile.com/app/p/9406c8b3-9f0c-0a5c-bb47-56729bb6b63f
Usefullness of synbiotic administration in preventing gastrointestinal sigs in cats receiving clindamycin
- No effect of synbiotic on vomiting statistically (although did trend lower), no effect on faecal scores.
- Cats with synbiotic treatment were more likely to complete treatment in the first period
- Cats had higher food intake when receiving the synbiotic.
https://paperpile.com/app/p/e85e0aea-b24a-0902-8dbf-2f88b2b74471
What gastrointestinal abnormality has been demonstrated in cats with chronic gingivostomatitis?
Oesophagitis is present in many cats with gingivostomatitis.
https://paperpile.com/app/p/171a4e0e-0c98-0603-846b-b294a28e0ca1
Risk factors for death in dogs that have oesophageal foreign body
Increasing number of post-procudural complications, oesophageal perforation, post-procedural haemorrhage. Surgery (OR 20.1)
https://paperpile.com/app/p/45896f59-403c-0492-889f-e96b00724d6c
Percentage of patients that have oesophageal stricture development following oesophageal foregin body removal
2.1%
https://paperpile.com/app/p/45896f59-403c-0492-889f-e96b00724d6c
What are the most commonly identified bacteria in dogs with cholecytopathy?
E. coli and Enterococcus spp.
What breed is commonly seen in dogs with ductal plate abnormalities and what other congential abnormalities can be expected?
Chihuahuas seem to be commonly affected.
PPDH/CPPDH are associated with DP abnormlities
What is the use of calprotectin in dogs with CE?
Correlated to activity indices, dogs with SRE have higher concentraitons than FRE/ARE (cut off ≥15.2ug/g). It also decreases in response to treatment
What intervention may help in outcomes of dogs/cats with oesophageal strictures?
Indwelling balloon dilation devide that results in a 10 fold reduction in dysphagia scores in these patients and 91.7% animals will improve with this intervention
What cup biopsy size is fine to sue for laproscopic liver biopsy?
3mm cups have been shown to have no benefit over 5mm cups in terms of diagnostic accurac but do result in fewer portal triads to examine
Which cytokines have been shown to correlate to hepatic fibrosis and necroinflammatory scores?
IL-6 = fibrosis
CCL2 = necroinflammation
What clincopathologic marker appears to predict recovery from PSS attenuation in dogs?
Albumin
What effect does feeding an animal protein-free diet have on dogs with FRE microbial diversity?
It improves biodiversity although flora of these animals may remain persistently differnt from healthy controls
What staining technique may be useful for demonstrating eosinophils and eosinophil degranulation in dogs with GI disease?
mAB to eosinophile granule protein eosinophile peroxidase
Which C. perfringens toxin genes have been found to be increased in the faeces of dogs wiht AHDS?
NetE and NetF which were present in 48.1% dogs with AHDS, none wiht parcovirus and 12.1% of healthy dogs
What histopathologic change on liver biopsy should prompt a hunt for leptospirosis?
Granulomatous inflammation