Oncology

Question 1

What are antimetabolites?

Answer 1

A group of molecules that impede DNA and RNA synthesis

Question 2

What does antifolates include

Answer 2

Methotrexate

Pemetrexed

Question 3

Methotrexate?

Answer 3

• inhibits DHFR
• all types of cancer
• orally / IV / IT

Question 4

SE of methotrexate

Answer 4

Myellosuppression

Mucositis

Nephrotoxicity

Neurotoxicity

Question 5

Pemetrexed?

Answer 5

• inhibits Thymidylate synthase & DHFR
• used for Mesothelioma & lung adenocarcinoma
• B12 & B9 supplements before

Question 6

SE of 5FU

Answer 6

Bolus : myellosuppression & angina

N/V : diarrhea - Mucositis - hand-foot syndrome

Question 7

Topoisomerase I inhibitors

Answer 7

Irinotecan (CAMPTO) - SE: diarrhea

Topotecan

Question 8

Topoisomerase II inhibitors

Answer 8

Etoposide

🔴Doxorubicin🔴 (EF of heart!) (dose less than 450mg/m2)

Question 9

Pyrmidinealogs (fluropyrmidines) drugs?

Answer 9

5-fluorouracil (5FU)

Capecitabine (5FU prodrug) (oral)

Fludarabine

Cladribine

Azacitidine

Question 10

🔴Doxorubicin🔴 SE

Answer 10

Cardiotoxicity

Alopecia

Mucositis

Vesicant (not inf)

Question 11

Antimicrotubules?

Answer 11

• plant derived
• Vinca alkaloids (prevent formation)
• Taxanes (prevent disassemble)

Question 12

Taxanes?

Answer 12

Paclitaxal (G2-M phase)

Docetaxel (S phase)

SE: muscle pain - myellosuppression

Question 13

Vinca alkaloids?

Answer 13

!Fatal! if given intrathecally

Vincristine

Vinblastine

Vinuflufin (bladder tumors)