Oncology

Question 1

Hepatoblastoma

Answer 1

Most common cause of a large liver mass in children, elevated alpha fetoprotein

Question 2

Wilms Tumor

Answer 2

Renal mass

Question 3

Tumor lysis syndrome lab values

Answer 3

elevated potassium, phosphorus, and uric acid levels

Can cause renal failure which will result in elevated BUN, creatinine and decreased calcium

Question 4

Non Hodgkins vs hodgkins

Answer 4

Non is and emergency, it’s fast acting

Question 5

Non Hodgkin presentation

Answer 5

Abdomen- mass n/v hematochezia pain
Mediastinum dysphasia Svc syndrome chest pain
Head/neck: facial swelling, snoring, rhinorrhea, cervical lymphadenopathy

Question 6

Neuroblastoma

Answer 6

Neoplasm of the sympathetic nervous system

Tumors in chest abdomen and pelvis

Question 7

Mediastinal mass presentation

Answer 7

Cough dyspnea hoarseness strider Orthopnea syncope tachycardia jvd cyanosis

Question 8

Tumor lysis syndrome presentation

Answer 8

Hyperurecemia hyperphosphatemia hyperkalemia hypocalcemia elevated ldh elevated creatinine arrythmias seizure
Caused by rapid release of lysed tumor cells

Question 9

TLS management

Answer 9

Aggressive hydration diuretics correct electrolytes allopurinol for hyperuricemia May need dialysis

Question 10

Hyperleukocytosis presentation

Answer 10

Headache tinnitus ataxia behavioral changes seizure
Lungs tachypnea resp distress hypoxia hemorrhage ARDS
Renal failure factuality’s priapism cardiac failure

Question 11

Typhlitis

Answer 11

Intra abdominal emergency
Inflammation of cecum
Rlq pain mucosutis
Give broad spectrum abx

Question 12

Neutropenia

Answer 12

Neutrophil count less than 500

Question 13

Febrile neutropenia evaluation

Answer 13

Blood culture
Clean catch urine (no cath)
Chest x ray if symptomatic
Respiratory and stool panel if symptomatic

Question 14

Abx for febrile neutropenia

Answer 14

Mono therapy with antipseudomonal beta lactam (carbenicillin, cefadroxil, ceohalexin or cephradine) or carbapenem (meropenem)

Question 15

Obsoclonus myoclonus is associated with what oncologic diagnosis

Answer 15

Neuroblastoma

Question 16

Autologous stem cell transplant

Answer 16

The patient receives their own peripheral blood or bone marrow

Question 17

Indications for autologous hsct

Answer 17

Solid tumor malignancies

Neuroblastoma Hodgkin lymphoma

Question 18

Allogenic hsct

Answer 18

A patient receives donated stem cells, peripheral cells or umbilical cord cells

Question 19

Indications for allogenic hsct

Answer 19

Malignant or non malignant diseases affecting the blood or bone marrow
Leukemia hemoglobinopathy immunodeficiency

Question 20

Hsct complications

Answer 20

Sinusoidal obstructive syndrome
Mucositis
Pancytopenia
Recurrence of disease
Gvhd
Infection

Question 21

Mucositis

Answer 21

Painful GI tract ulcerations

Question 22

Symptoms of Mucositis

Answer 22

Vomiting anorexia diarrhea increased oral secretions severe pain bleeding

Question 23

Sinusoidal obstructive syndrome

Answer 23

Endothelial damage
Portal hypertension leading to hepatocyte necrosis
Dysregulated coagulation

Question 24

SOS symptoms

Answer 24

Fluid overload hepatomegaly hyperbolili wt gain

Question 25

Target organs in gvhd

Answer 25

Skin, gut, liver

Question 26

Congenital anomalies associated with pilyhydramnios

Answer 26

Anacephaly hydrocephaly TEF duodenal atresia spina bifida cleft lip/palate DH achrondroplasia T21 T18 TORCH hydrops