Oncogenes - gain function - increased cancer risk. Need damage to only 1 allele Flashcards by Ngoc Vu | Brainscape

Q

ALK

A

Receptor tyrosine kinase Lung adenocarcinoma

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Q

BCR-ABL

A

Tyrosine kinase

CML, ALL

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Q

BCL-2

A

Antiapoptotic molecule (inhibits apoptosis)

Follicular and diffuse large B cell lymphomas

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Q

BRAF

A

Serine/threonine kinase

Melanoma, non-Hodgkin lymphoma

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Q

c-KIT

A

Cytokine receptor

Gastrointestinal stromal tumor (GIST)

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Q

c-MYC

A

Transcription factor Burkitt lymphoma

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Q

HER2/neu (c-erbB2)

A

Tyrosine kinase

Breast and gastric carcinomas

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Q

JAK2

A

Tyrosine kinase

Chronic myeloproliferative disorders

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Q

KRAS

A

GTPase

Colon cancer, lung cancer, pancreatic cancer

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Q

MYCL1

A

Transcription factor

Lung tumor

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Q

MYCN

A

Transcription factor

Neuroblastoma

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Q

RET

A

Tyrosine kinase

MEN 2A and 2B, medullary thyroid cancer

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