ACUTE PHASE REACTANTS - produce by liver during acute and chronic inflammation - induce by IL6

Question 1

C-reactive protein

Answer 1

UPREGULATED

Opsonin; fixes complement and facilitates phagocytosis.
Measured clinically as a sign of ongoing inflammation.

Question 2

Ferritin

Answer 2

UPREG

Binds and sequesters iron to inhibit microbial iron scavenging.

Question 3

Fibrinogen

Answer 3

UPREG

Coagulation factor, promotes endothelial repair, correlates with ESR

Question 4

Hepcidin

Answer 4

UPREG
dec iron absorption (by degrading ferroportin) and dec iron release (from macrophages) –> anemia of
chronic disease.

Question 5

Serum Amyloid A

Answer 5

UPREG

Prolonged elevation can lead to amyloidosis

Question 6

Albumin

Answer 6

DOWN REG

Reduction conserve amino acids for positive reactant

Question 7

Transferrin

Answer 7

DOWN REG

Internalized by macrophages to sequester iron