Onco Flashcards
classic s/s bladder ca
painless hematuria
causes of bladder ca
- tobacco/cigarette smoking
- occupational chemical exposure
- ⬆️ fat intake
live virus immunization
not allowed and also their household contacts
measles, mumps, rubella, polio
varicella
shingles & some flu virus like H1N1
polio vaccine alternative
Salk vaccine (inactivated)
eliminate in child’s room
raw fruits & vegetables
fresh flowers & live plants
standing water
given to stimulate bone marrow to produce white blood cell
(Granulocyte Colony Stimulating Factor)
G CSF / Filgrastim (Neupogen)
air flow in rooms
(high efficiency particulate air)
HEPA Filter
or
laminar air flow system
- sucks air and thru a filtration, removes pollen, dust, mold, bacteria, airborne particles
pedia bleeding prec
-measure abdominal girth
-soft toothbrush
-cool to warm soft foods
-avoid injections, if possible
-apply firm and gentle pressure to a needle-stick site for at least 10 minutes
-pad side rails and sharp corners -avoid constrictive or tight clothing. -avoid blowing nose
-avoid the use of rectal suppositories, enemas, and rectal thermometers
-count the number of pads or tampons used if the adolescent girl is menstruating
-avoid NSAIDs and aspirin
Late Signs of ⬆️ ICP
▪ Bradycardia
▪ Decreased motor response to command
▪ Decreased sensory response to painful stimuli
▪ Alterations in pupil size and reaction
▪ Decerebrate (extension) or decorticate (flexion) posturing
▪ Cheyne-Stokes respirations
▪ Papilledema
▪ Decreased consciousness
▪ Coma
early signs of ⬆️ ICP for infants
- tense bulgung fontanel
- irritability
- high pitched cry
- poor feeding
- setting sun sign / sunset eyes
- Macewen’s sign (cracked pot sound after percussion)
- increased head circumference
- distended scalp veins
- separated cranial sutures
early signs of ⬆️ ICP for children
▪ forceful vomiting, nausea
▪ headache
▪ Seizures
▪ Diplopia; blurred vision
⬆️ ICP personality & behavior signs
▪ Irritability, restlessness
▪ Indifference, drowsiness
▪ Decline in school performance
▪ Diminished physical activity and motor performance
▪ Increased sleeping
▪ Inability to follow simple commands
▪ Lethargy
Leukemia
malignant increase of immature WBC in the bone marrow resulting in:
💀neutropenia - risk for infection
💀anemia -tired, SOB, weak
💀thrombocytopenia - risk for bleeding
common in boys than in girls
most frequent type of cancer in children
acute lymphocytic leukemka
phases of chemotherapy for leukemia
- induction - complete remission or disappearance of leukemic cells
- intensification or consolidation - decreases the tumor burden further
- central nervous system prophylactic therapy - prevents leukemic cells from invading the central nervous system
- maintenance - maintain remission phase
confirmatory for leukemia
+ bone marrow biopsy of blast cells
hair loss may occur from chemotherapy
hair regrows in about 3 to 6 months and may be a slightly different color or texture
Hodgkins Lymphoma
malignancy of the lymph nodes
painless/non tender, firm, enlarged, movable lymph nodes
supraclavicular
or
sentinal node in children
confirmatory of hodgkins lymphoma
+ Lymph node biopsy of Reed-Sternberg cells
nephroblastoma
Wilms’ Tumor
peaks at 3y.o.
intraabdominal and kidney tumor
DO NOT PALPATE ABDOMEN
measure abdominal girth daily
➕hypertension (⬆️renin bec tumor)
neuroblastoma
poor prognosis
peaks before 10y.o.
⬆️immature neuroblast cells forming tumor in adrenal gland or retroperitoneal
+ in urine: vanillylmandelic acid, homovanillic acid, dopamine, and norepinephrine
Osteosarcoma
osteogenic sarcoma
most common bone cancer in children, peaks 10-25yo
tumor in metaphysis of long bones, mostly in femur
earliest sign: extremity injury or normal growing pains relieved by a flexed position
-limping during weight bearing
-pathological fractures
treatment: limb salvage/limb resection procedure
brain tumors
-headache severe at waking up & improves within the day
-vomiting
-ataxia
-diplopia
-facial weakness
-clumsiness
no trendelenburg/supine
no to operative side
-infratentorial:flat on either side
-supratentorial: above heart level
monitor temperature!
monitor CSF leakage:
-colorless drainage in the dressing or from ears/nose
-dipstick for +glucose = CSF
opisthotonus
backward arching of the spine bec of meningitis
nadir
the time where bone marrow activity & wbc counts are at lowest
types of biopsy
- needle
- incisional - part/wedge
- excisional - whole
- staging - multiple needle & incisional
types of oncological surgeries
- prophylactic - premalignant
- curative - affected organ only
- controlled (cytoreductive/controlling) - affected organ & adjacent
- palliative - alleviate symptoms
- reconstructive/rehabilitative - for altered body image
external beam radiation
teletherapy
patient NOT RADIOACTIVE
-wash gently each day with warm water alone or with mild soap and water
-use hand rather than a washcloth
-rinse soap thoroughly
-do not to remove the markings
-dry with patting motions rather than rubbing motions; use a clean, soft towel or cloth
-no powders, ointments, lotions, or creams
-wear soft clothing over the skin
-avoid wearing belts, buckles, straps, or any type of clothing that binds or rubs the skin
-avoid exposure to heat and the sun
internal radiation
brachytherapy
patient RADIOACTIVE
unsealed radiation source
a type of brachytherapy
patient RADIOACTIVE for 48hrs until excreted
given PO or IV into body cavities
thus body fluids are radioactive
excreta is also radioactive
sealed radiation source
a temporary or permanent implant, implanted in the target tumor
patient RADIOACTIVE
excreta NON RADIOACTIVE
patient becomes NON RADIOACTIVE after implant removal
dislodged sealed radiation implant
lie still
long handled forceps
deposit in a lead container
contact oncologist
document
types of donor stem cells
autologous - self sourced
syngeneic - twin
allogeneic - relative or non relative
BMT harvest
bone marrow transplantation harvest
-multiple aspirations of stem cells from the iliac crest
-allogeneic or syngeneic marrow, transferred immediately
-autologous marrow, filtered for cancer cells and are frozen (cryopreservation)
PBSCT Harvest
peripheral blood stem cell transplantation harvest
-like a dialysis machine, for 4 to 6hrs, blood removed thru central venous catheter and thru apharesis or leukapharesis, removes stem cells and returns the rest of the blood to the blood stream
conditioning
done after harvesting
immunosuppresion therapy eradicating all malignant cells creating space in bone marrow for engraftment
transplantation (stem cell)
given iv or iv push thru central line like a blood transfusion
engraftment
blood cell counts begin to rise
process takes 2 to 5 weeks
post transplantation (stem cell)
most critical period
patient at risk for bleeding, infection until engraftment
complications of stem cell transplantation
- failure to graft
- graft vs host disease - esp in allogeneic, managed thru immunosuppressive agents
- hepatic veno-occlusive disease - occlusion bec of thrombosis / phlebitis
s&s
right upper quadrant abdominal pain
jaundice
ascites
weight gain
hepatomegaly
leukamia pts to avoid doing
changing litter box
working w/ house plants/garden
going to crowds
adult bleeding prec
same w/ pedia
-for injection, press for 5mins or more instead of 10 mins
-count tampons/pads for menstruating
-use of electric razor
-soft toothbrush and NO dental floss
-avoid blowing nose