Olfactory/Gustatory Physio Flashcards
5 categories of tastants
- Sour
- Salty
- Sweet
- Bitter
- Umami
Umami is associated with…
Glutamate
Bitter is associated with…
Poisons/Coffee
Tastants associated with Ca2+ triggered release of serotonin
Salty and Sour
Tastants associated with Ca2+ triggered release of ATP
Sweet, Umami, Bitter (SUB)
What receptor is crucial in the release of ATP?
TRPM 5
What 3 cortical areas make up the gustatory cortex?
- Postcentral gyrus
- Frontal operculum
- Insula
Which parts of the pathway are responsible for the discriminative aspects of taste?
VPM and Gustatory cortex
Which parts of the pathway integrate visual, somatosensory, olfaction and gustatory stimuli?
Orbitofrontal cortex
Role of nucleus tractus solitarius
Receives afferents from CN VII, IX and X for taste, as well as other visceral info from CN X.
It also regulates medullary reflex arcs (swallowing, salivating, etc.)
What type of cells are olfactory cells?
Bipolar cells (very adaptable)
What type of receptors are olfactory receptors?
GPCRs
Describe how the olfactory system adapts to smells
As odorant stimulation persists, sensitivity of CNGC to cAMP decreases, thus reducing cation influx.
Can also be inactivated by receptor phosphorylation
How do odor receptors detect more smells than there are receptors?
- Combos of different stimuli act like signatures
- Concentration of odorant affects perception of smell
Purpose of granular cells?
- Local interneurons that release GABA to increase specificity of signal