Olanzapine

Question 1

Olanzapine: Introduction

Answer 1

Olanzapine is a second generation antipsychotic agent that acts on multiple receptors (incl seratonin and dopamine receptors) resulting in sedation

Use of a sedative agent should never be considered routine. Adopt a high threshold to offer or administer

Question 2

Olanzapine: Indication

Answer 2

DAB (Rass1-3) if considered appropriate where risk to safety is evident and de-escalation has not been effective

Patient is able to tolerate or self-administer an oral wafer

Preffered first-line sedation agent in frail patients and those with Dementia

Question 3

Olanzapine: Contraindication

Answer 3

Hypersensitivity

Known Parkinsons Disease

Age <6 years old

Question 4

Olanzapine: Considerations

Answer 4

Extrapyramidial effects/ Dyskinesia

Increased falls risk

Hypotension: Apply monitoring as soon as practicable