Atropine

Question 1

Atropine: Introduction

Answer 1

An anticholinergic agent that inhibits the action of acetylcholine on post ganglionic nerves at the neuroeffector site. This blocks vagal stimulation to allow the sympathetic response to increase pulse rate by increasing SA node firing rate and increasing conduction velocity through the AV node.

An antidote to reverse the effects of cholinesterase inhibitors such as seen in organophosphate poisoning.

Question 2

Atropine: Indications

Answer 2

1) Symptomatic bradycardia, haemodynamically unstable due to the bradycardia and associated with poor signs of perfusion including
- hypotension
- altered conscious state
- diaphoresis
- shortness of breath and/or cyanosis
- syncope

2) Organophosphate poisoning with cholinergic effects

Question 3

Atropine: Contraindications

Answer 3

1) Known Hypersensitivity
2) Patients with Cardiac Transplant

Question 4

Atropine: Considerations

Answer 4

THCDD

Tachycardia and/or palpitations
Hot dry skin
Confusion, restlessness
Dilated pupils and/or blurred vision
Dry mouth and/or urinary retention