Okaps flashcards - Retina
what type of collagen is vitreous?
type II
what are elschnig spots
choroidal infarcts in severe hypertensive retinopathy
tertiary vitreous forms what structures?
zonules
stickler’s systemic findings
hyperextensible joints, arthritis, orofacial findings, cleft palot Pierre Robin malformation complex
Causes of bull’s eye maculopathy
drugs (chloroquine, chlopromazine, thioridzine, tamoxifen), confe dystrophy, stargardt’s disease, inverse RP Batten’s disease
what is wrong in gyrate atrophine
error of ornithine aminotrasferase leading to increaed ornithing
treatment of gyrate atrophy
pyridoxine and arginine restricted diet
risk factors for ROP
born less thant 36 weeks, less than 2000 g
threshold diseas
stage 3 ro with , zone 1 or 2 invovled, 5 or more continuous clock hours or 8 cumulative clock hours, plus disease
when should ROP be screened
4-6 weeks after birth or 30 weeks, which ever is later.
how often does ROP regress?
85%
degenerative retinoschsis in myopes or hyperopes
hyperopes
ERG finding in X linked retinoschisi
B wave decreased compared to a wave
retinoschiss vs. RD
schisis absolute scotoma
DRVS study
benefit of early vitrectomy in type I, not in type II
what is a Fuch’s spot
pigment proliferation after absorption of macular hemorrhage from CNV in highly myopic individuals
Bull’s eye maculopathy
chloroquine toxicity, cone dystrophy, Bardet Biedel syndrome, Batten’s inverse RP, macular dystrophy, stargardt’s
what are signs that choroidal nevus is malignant
subretinal fluid, orange pigment, growth, symptoms,
Ddx for decrase in b wave
siderosis, congeneital tationary night blindness, CRAO, qinne or methanol toicity, X linked retinoshisis
EOG
measures RPE function
Ocular findings in RP
PSC, myopia, optic disc drusen, KCN, glaucoma, Intermediate uvietis, PVD
Refsum’s disease
increase in phytanic acid, pig retinopathy, cataracts, cerebellar ataxia, deafness
What mucopolysaccharidoses associated with pigment retinopathy?
Hurler, hunter, scheie, sanfilippo
Oguchi’s disease
recessive form of stationary night blindnes 2-12 hr delay of attaining normal dark adapted rod thresholds
Fundus albipunctatus
recessive form of stationary night blindness, tiny yellow white spots sparing macula
what is the specificity gravity of silicone oil
0.975, slightly less than fluid in vitreous
where do trasumatic retinal dialyses occur
superonasal
difference between classic and occult CNV
classic hyperfluoresecen very early with boundaries, ocul hyperfluoresces later, may have indistinct borders
AR, chromsome 16 obesity, polydactyly, hypogonadism, MR, pigmentary retinopathy
Bardet-Biedell syndrome
ichthyosis and pigmentary retinopathy
Refsum and sjogren larsson
patients’ about 40, bilateral subfoveal NVM
Sorby’s macular dystrophy
ddx for crystalline retinopathy
tamoxifin, thioridizine, cystinosis, canthaxantin, primary hyeroxaluria, Bietti’s talc retinophaty
laser photocoagulation schsis vs. RD
will be visible in outer layer of schiss, but not on bare RPE of RD
ddx of intraocular cartilage
PHPV, medulloepithelioma, teratoma, trisomy 13
five stages of ROP
line, rdige, ridge with vessels, RD (foveal and nofoveal), total funnel RD
ddx of periphery retinopath and macular dragging
incontnetia pgimenti, ROP, FEVR, x linked retinoschis
associations with best
strabismus, hyperopia
nonleaking CME
Goldmanfavre, retinoschiss nicotinic acid, RP
onset in 1st decade with drusen leding to atrophy
north caroline macular dystrophy (AD) ERG, EOG, normal
decreased VA between 40-50
Sorsby’s AD ERG and Eog subnormal late
central pigmentary distrubances, good central VA, normal ERG, abnormal EOG
pattern dystrophies
severely reduced vision, complete color blinness, nystagmus, normal retinal exam
congenital achromatopsia
decreased vision, photoaversion, nystgamus. ERG: absent cone response, normal rod
blud cone monochromatism (X linked recessive)
which type of RP is worse?
X linked
type of scotoma in RP
inferotemporal
ddx of tunnel vision
glacuoma, functional, gyrate atrophy, vitamin A toxicity, occipital lobe stroke
ddx of nyctalopia
myopia, vitamin A, zinc deficincy, choroidemia, gyrate atrophy, CSNB, goldman favre
ddx salt pepper fundus
rubuella, leber’s amaurosis, albinism, RP, syphilis, cystinosis, phenothiazine toxicity, pattern dystrophy
treatable RP
Bassen kronzweigh (abetalipoproteinemia), refsums’s, gyrate atrophy
associations with LCA
chromosme 1, KCN, hyperopia, cataract, macular colobomia, MR< deafness, seizures, renal and muscloskeletal abnormaliteis
inverse RP
posterior pole more than periphery affected
punctata albescene
small white spots in mid periphery, no bone spiculares
deafness and RP
Usher’s Hallgreen’s alstrom’s biedle bardet
eye syndromes with hearing loss
cogan’s sticklers’s waardenburg-Klein, Duane’s
increased serum copper, ceruloplasmin, atypical RP
Refsum’s
RP due to differntiacy in fat soluble viamins
CBC, cholesterol, stool, bassenkornzweig
RP due to vitamin deficiency
chronic pancreatitis, cirrhosis, bowel ressection
obesity, polydactyl, mental retardation, hypogonadism, short stature
biedl-Bardet syndrome
decreased vision 4th decade, rpe mottling
central arelolar choroidal dystrophy (AD)
decreased vision in 5th decade, yellow crystal in retina, corneal stroma
Bietti’s ((AR)
normal vision, vf, color vision, may show paradoical pupillary dilation, scotopic photopic implicit times identical, decreased scotopic, photopic erg almost normal
congenital stationary night blindness
types of CSNB
fundus albipunctatus, oguchi’s diasee, kandori’s flecked retina, nourgaret and riggs type ( normal fundus)
femal carriers have salt and pepper fundus
chorooidemia, defect in choroidal vasculature (XLR)
scallaped areas of absent choriocapillus, seizures, increased ornithine
gyrate atrophy
corneal clouding and retinopathy
Huerl’er sna dScheie
Retinopathy only
Hunter’s, Sanfilippo
Corneal changes only
Morquio, Maroteaux-Lamy
no corneal clouding or retinopathy
Sly
Sphingoliposdes with cherry red spot
Tay Sach’s, Sandoff’s, Neiman Pick, Guaucher
sphingolipodoes without cherry red spot
Fabry’s, Krabbe’s
composition of vitreous
99% water, type Ii colagen, volume 4ml
how many rods, how many cones?
120 million, 6 million
describe visual cycle
11 cis retinaldehyde turns into all tran
when do rods shed? Cones shed?
rods- during day, cones at night.
conditions which cause extinguished erg
rp, opthalmic artery occlusion, dusn, metallosi, rd, drug toxicity CAR
normal a wave, reduced b wave
CSNB, Oguchi’s disease, x linked retinoschis, CVO, CRAO, myotonic dystrophy, quinine toxicity
abnormal photopic, normal scotopic
achromotopsia, cone dystrophy
abnormal erg, normal eog
csnb, x linked retinoschisis
fluoroscein absorptiona and emission
absorb 490 nm, emits 530.
uses of ICG
IPCV, occul CNV, NV with PED, recurrent CNV
AREDS formulation
vitamin C, E, betacarotein, zinc
Causes of CME
DEPRIVEN- Diabetes, epinpehrine, prostaglandins, RP, Irvine Gass, venous occlusion, pars palnitis, nicotinic acid maculopathy, othere XRT, parafoveal telangicectasia, goldmann FAVRE
causes of non leaking CME
Juvenile retinoschiss, goldman favre, RP, nicotinic acid maculopathy
type 1 mactel
unilateral, male?fmeale, coats spectrume, normal FA, OCT is not.
type 2 mactel
bilateral, acquired, symmetric
5 stages of sickle cell
periphery arterial occlusions, peripheral anastomoses, NV (sea fan, VH, vitreous traction with RD.
bilateral, young men, in middle east, india, peripheral nonperfusion
Eales disease
definition of ischemic vs. nonischemic BRVO
ischemic»_space;5 DD nonperfusion
threshold dose for radiation retinopathy
300 rads, starts 6 months to 3 years after.
decreased vision RAPD, neuroretintisi, hot disc
Leber’s idiopathic stellate neuroretinitis
organisms for DUSN
ancylostoma caninum, baylisacris proncyonis
toxic retinopathies
chloroquine, thioridazine, chlorpormazine, quinine, tamoxofen (crystals), canthaxanthin (yellow deposits, methoxyfluorine, talc
atypical nonleaking CME due to intracellular edema of Muller’s cell
nicotininc acid maculopathy
combined harmartoma of retina nad rpe association
nf2
hihg energy radioactiv plaques
cobalt 60, iridum 192
low energy plaques
iodine 125, palladium 106
small COMTs trial
apical height 1-3 mm, basal 5-16mm
medium comt trial
apical 2.5-10m, basal <16, enucleation same as radiation
large COMT trial
preenucleatioin radiation does not change survival rate.
ddx of amelanotic choroidal mass
amelanotic melanoma, choroidal osteoma, granuloma, porsterior scleritis