Occupational lung disease (RESP) Flashcards

1
Q

Define occupational lung disease.

A

Long-term exposure to irritants being inhaled into lungs - any respiratory disease that is caused or made worse by exposures at work

AKA pneumoconiosis

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2
Q

What are pneumoconioses (occupational lung disease)?

A

Group of interstitial lung diseases, mostly of occupational origin, caused by the inhalation of mineral or metal dusts

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3
Q

What are the two main types of occupational lung disease?

A
  • sensitiser-induced: immunological stimuli - latency between first exposure and onset of symptoms
  • irritant-induced: non-immunological stimuli
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4
Q

What are some common irritants and the type of occupational lung disease they cause? (4)

A
  • coal - coal worker’s pneumoconiosis
  • asbestos - asbestosis/asbestos-related lung disease
  • silicon - silicosis
  • beryllium - berylliosis
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5
Q

What are some common types of occupational lung disease? (8)

A
  • COPD
  • asthma
  • lung cancer
  • infectious diseases
  • pneumoconiosis
  • asbestos-related lung disease
  • silicosis
  • allergic alveolitis
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6
Q

When should occupational asthma be suspected?

A

In all adult patients with asthma

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7
Q

Which occupation is coal workers’ pneumoconiosis most common in?

A

Coal miners - diagnosis usually 15-20 years after initial exposure to coal dust

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8
Q

How does simple pneumoconiosis present?

A

Asymptomatic

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9
Q

Which condition does simple pneumoconiosis increase the risk of?

A

COPD

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10
Q

What condition may simple pneumoconiosis lead to?

A

Progressive massive fibrosis

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11
Q

How does progressive massive fibrosis (occupational lung disease) present? (2)

A
  • exertional SOB
  • cough +/- black sputum
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12
Q

Which lobes does progressive massive fibrosis (occupational lung disease) most commonly affect?

A

Upper lobes

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13
Q

What is found on CXR in (coal workers’) pneumoconiosis?

A

Upper zone fibrosis

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14
Q

What will spirometry show in (coal workers’) pneumoconiosis?

A

Restrictive pattern

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15
Q

What is silicosis (occupational lung disease)?

A

Fibrotic lung disease caused by inhalation of silica

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16
Q

Which condition is silicosis a risk factor for?

A

TB

17
Q

Which occupations is silicosis most prevalent in? (3)

A
  • stonemason
  • pottery
  • ceramics
18
Q

What do we see on CXR in silicosis (occupational lung disease)?

A

‘Egg shell’ calcification of hilar lymph nodes

19
Q

What conditions are linked to asbestos exposure (occupational lung disease)? (2+3)

A
  • asbestosis
  • mesothelioma- malignant disease of the pleura:
    • progressive SOB
    • chest pain
    • pleural effusion
20
Q

What substance is the most common cause of occupational asthma?

A

Isocyanates

21
Q

What are the clinical features of occupational lung disease? (4)

A
  • insidious onset SOB
  • cough + sputum production / dry
  • black sputum = melanoptysis - coal workers’ pneumoconiosis
  • pleuritic chest pain - due to acute asbestos pleurisy
22
Q

What is seen on examination in occupational lung disease? (2)

A
  • similar to any respiratory condition especially intersitital lung disease
  • coal workers’ pneumoconiosis + silicosis: decreased breath sounds
23
Q

What are some risk factors for occupational lung disease? (4)

A
  • high exposure
  • previous respiratory conditions
  • genetic factors
  • cigarette smoking
24
Q

What exposures are risk factors for occupational lung disease? (4+4)

A
  • coal
  • asbestos
  • silica
  • beryllium
  • spray painting/foam product manufacture
  • welding, soldering, cutting/grinding metals
  • dusts: stone, cement, brick, concrete
  • general work environment
25
Q

What are the first-line investigations for occupational lung disease? (4)

A
  • CXR (PA and lateral)
  • spirometry (pre- and post-bronchodilator)
  • beryllium lymphocyte proliferation test (BeLPT)
  • CT
26
Q

What might CXR show in occupational lung disease?

A

Hyperinflation, nodular appearance
Complicated disease:

  • nodular opacities in upper lobes
  • micronodular shadowing
  • silicosis: ‘egg shell’ calcification of hilar lymph nodes
27
Q

What might spirometry show in occupational lung disease?

A

Obstructive or restrictive disease - depending on cause

28
Q

Why might skin prick test be useful in occupational lung disease?

A

To find allergen

29
Q

What are some differential diagnoses for occupational lung disease? (6)

A
  • occupational asthma
  • work-exacerbated asthma (preceding before job)
  • occupational eosinophilic bronchitis (cough at work without wheeze)
  • hypersensitivity pneumonitis (CXR: patchy nodular infiltrates and fibrosis)
  • COPD
  • vocal cord dysfunction (PFTs show extrathoracic vocal airflow limitation)
30
Q

How do we manage sensitiser-induced occupational asthma?

A
  • removal from any further exposure to agent
  • ICS and bronchodilators
31
Q

How do we manage irritant-induced occupational asthma?

A

Preventative measures implemented in workspace to reduce further exposure and episodes

32
Q

How do we manage silicosis AKA acute secondary alveolar proteinosis? (3)

A
  • lung lavage
  • smoking cessation
  • removal of occupational exposure
33
Q

How do we manage berylliosis?

A

Oral corticosteroid - prednisolone 40-70mg OD then taper gradually