Obstructive Lung Disease

Question 1

What is the pathogenesis of asthma?

Answer 1

Chronic inflammation-> airway narrowing-> airflow limitation

Question 2

What else happens in asthmatic lungs?

Answer 2

Airway smooth muscle hypertrophy, leukocyte infiltration, goblet cell hyperplasia and mucus hypersecretion

Question 3

What is the pathology of asthma?

Answer 3

Allergens activate sensitised mast cells by crosslinking surface bound IgE to release mediators leading to bronchoconstriction

Question 4

What is the Th2 response in asthma?

Answer 4

They release IL4 and IL13 causing B cells to synthesis IgE. IL5 activates eosinophils and IL9 mast cell proliferation

Question 5

What is non T2 asthma?

Answer 5

Late onset, associated with obesity, smooth muscle mediated, neutrophilic, smoking related

Question 6

What are the symptoms of asthma?

Answer 6

Cough, dyspnoea, chest pain, allergies

Question 7

Asthma structured clinical assessment?

Answer 7

Recurrent episodes, symptom variability, recorded wheeze, atopy, PEF FEV