Cardiomyopathy Flashcards
How can cardiomyopathies be classified?
Genetic/ non genetic, hypertrophic/ dilated/ restrictive
What is dilated cardiomyopathy?
Characterised by enlargement of chambers and decreased systolic function, usually left side.
What can cause cardiomyopathy?
Genetic mutation, infection, inflammation
How is cardiomyopathy defined?
Disease that can’t be explained by CAD or abnormal loading- arise from within the heart
How is dilated cardiomyopathy diagnosed?
Rule out other causes. ECG, CXR, echo, cardiac catheterisation
How is dilated cardiomyopathy treated?
Medication to control symptoms- BBs, anticoags, diuretics, ACEis, ARBs. ?Blood thinners. Transplantation
What is hypertrophic cardiomyopathy?
Septal thickening leads to MV dysfunctional and LV outflow obstruction. Variable phenotypes. Hereditary. Can cause sudden death in YPs. Majority are fine.
What are the signs and symptoms of hypertrophic cardiomyopathy?
Can be nothing can be severe. Treat symptoms.
What is the most common mutation causing hypertrophic cardiomyopathy?
Myosin binding protein C. Regulation of crossbridge cycling?
What is restrictive cardiomyopathy?
Least common and most fatal. Stiff myocardium.
What causes restrictive cardiomyopathy?
Fibrosis, systemic disease, GSDs, tumours, genetic, idiopathic
What is arrhythmogenic RV cardiomyopathy?
Rare. Tends to be inherited. Mutations in cardiac desmosome where adipose and fibrotic tissue replace cardiomyocytes. RV enlarges leading to arrhythmias
