Obstetrics Flashcards
Maternal Reasons for Induction of Labour? (7)
Gestational Diabetes, Hypertension & Obstetric Cholestasis. Maternal Request. Prolonged pregnancy (>41-42w) Symphysis Pubis Dysfunction Recurrent Antenatal Haemorrhage.
Fetal Reasons for Induction of Labour? (5)
IUGR Reduced fetal movements. Previous Stillbirth or Current Intrauterine Death Prolonged Pregnancy Isoimmunisation
Contraindications to induction of labour? (5)
Previous uterine surgery or lower segment C-section. Active genital herpes & HIV Placenta praevia & Vasa Praevia Umbilical cord prolapse Abnormal lie
What are the risks of induction of labour? (7)
Failure leading to need for C-Section or operative vaginal delivery.
Uterine hyperstimulation
Uterine rupture
Cord prolapse
Fetal Compromise
Intrauterine infection (chorioamnionitis)
Post-partum haemorrhage
What is the step-by-step interventions used for induction of labour? Before-during
Before: Membrane Sweep w finger.
Start: Prostaglandin
Oral/Gel - one dose/6hrs then another (max 2)
Pessary - one dose/24 hours
If frequent/long contractions: Amniotomy
What is the risk of prostaglandin for induction of labour?
Risk of uterine hyperstimulation
What do you monitor during induction?
CTG for fetal wellbeing
What if the mum cant take prostaglandins due to risk of uterine hyperstimulation?
Amniotomy with or without oxytocin.
What happens if hyperstimulation occurs during induction of labour?
tocolysis
What happens if uterine rupture happens during induction of labour?
emergency c-section
Maternal (1) and foetal (3) complications of preterm-prelabour rupture of membrane?
M: Chorioamnionitis
F: Infection, respiratory hypoplasia, prematurity
Management of PPROM
Admit for observation and also start antibiotics.
Erythromycin (PO) for 10 days and corticosteroids (respiratory)
Consider delivery if past 34 weeks.
Risk factors for Gestational Diabetes
- Previous Gestational Diabetes
- First degree relative with Diabetes
*Previous baby > 4.5kg (macrosomia)
Previous unexplained stillbirth
*BMI > 30
Age > 40
*Racial origin
Smoking
Polyhydramnios
Persistent glycosuria
Polycystic ovarian syndrome
Maternal Complications of Gestational Diabetes
Worsens pre-existing Ischaemic Heart Disease, hypertension and pre-eclampsia
UTIs and endometrial infection
Can develop T2DM
Ketoacidosis and hypoglycaemia
Diabetic retinopathy and nephropathy
Caesarean & instrumental delivery
Foetal complications of gestational diabetes
Fetal compromise, fetal distress in labour,
Sudden fetal death
Macrosomia, shoulder dystocia
Hyperinsulinaemia/Hypoglycaemia
Polyhydramnios
Preterm labour
Reduced lung maturity
Neural tube & cardiac defect
What diabetes medication can u continue and not ?
Continue metformin +- insulin
Stop all other oral glucose lowering drugs.
In terms of heart related drugs what should be discontinue pre-conception and during pregnancy?
ACE-I & Angiotensin 2 receptor blockers
Statins
True or False?
Use fasting plasma glucose, random blood glucose, HbA1c, glucose challenge test or urinalysis for glucose to assess risk of developing gestational diabetes.
False. Do not use fasting plasma glucose, random blood glucose, HbA1c, glucose challenge test or urinalysis for glucose to assess risk of developing gestational diabetes.
What investigations can mums get if they are at risk of Gestational Diabetes?
2hr 75g oral glucose tolerance test.
If previous gestational, offer asap after booking and then 24-28 weeks if normal initially.
If not just 24-28 weeks.
What is a diagnostic result for Gestational Diabetes?
Either:
Fasting equal to or more than 5.6 mmol/L
2hours plasma glucose of more than or equal to 7.8 mmol/L
Management for GD?
Advice regarding diet and exercise.
Referral to a dietician.
Metformin (if exercise aint cutting it after 1-2 weeks)
If still not met, add insulin.
If fasting above 7 mmol/L from the start, just go straight to insulin with or without metformin.
If there are complications, then can start insulin from 6.
Pruritus affecting palms and soles.
Investigations show: elevated bile salts and liver enzymes during 3rd trimester?
Obstetric Cholestasis
Risk factors for Obstetric Cholestasis?
Multiple pregnancy (Twins)
Calculi - gallstones
Hepatitis C
What investigations would you order in a pregnant woman presenting with itch (palms and soles) but no rash.
Bedside: urinalysis (proteinuria) and blood pressure
Blood:
Liver function test & Bile Acids
Hepatitis ABC, EBV, CMV
Liver auto-immune antibodies - PBC (anti-SMA, anti-mitochondrial antibodies)
Imaging: Liver ultrasound
What is the definitive management for Obs Chole?
Delivery (IoL at week 37)
Ursodeoxycholic acid and sedating anti-histamines (chlorphenamine)
What is the triad for Hyperemesis Gravidarum?
Dehydration, more than 5% pre-pregnancy weight loss and electrolyte disturbances
What is the PUQE score?
Management stratification for HGE.
What are the risk factors for HGE?
Multiple pregnancy & Obesity
Nulliparity
Trophoblastic disease
Hyperthyroidism
What is first line treatment for HGE?
antihistamines (promethazine or cyclizine) –> odansetron or metoclopramide (max 5 days)
Complications of HGE?
Mallory Weiss Tear Central Pontine Demyelination Acute Tubular Necrosis Wernicke's Encephalopathy Foetal: SGA, pre-term birth
Causes of polyhydramnios?
Hint - increased fluid production & impaired swallow
Increased fluid production: Maternal diabetes & hydrops fetalis due to: rhesus haemolysis, infection (CMV, parvovirus), trisomies and anaemia.
Impaired swallow: duodenal/oesophageal atresia, neuromuscular disease (myotonic atrophy), idiopathic
Complications of polyhydramnios [2]
Prematurity & malpresentation
What is pre-eclampsia?
What is gestational hypertension?
New onset hypertension (>140mmHg systolic or >90mmHg diastolic) after 20 weeks of pregnancy with proteinuria or major organ dysfunction (renal, liver, neurological, haematological, urteroplacental)
G.Htn: New onset hypertension (>140 or >90) without proteinuria
What are the risk factors (High and moderate) for pre-eclampsia?
High:
- Hx of previous hypertension disease in previous pregnancies
- Chronic Hypertension
- Chronic Kidney Disease
- T1/2DM
- Autoimmune disease (SLE, anti-phospholipid)
Moderate:
- Nulliparous
- Multiple pregnancy
- BMI > 35
- Pregnancy interval more than 10 years
- More than 40 years old
- Family history of pre-eclampsia
What 3 investigations would you order to investigate pre-eclampsia?
Urine dipstick = 0/+1/+2
24 hour urine collection = > 0.3g/24hr
Protein:creatinine ratio = >30mg/nmol
Urine dip for protein = 0/+1/+2
What is HEELP syndrome?
A severe form of pre-eclampsia associated with:
Risk factors for ectopic? [6]
Previous ectopic IVF Surgery or salpingitis Endometriosis IUCD Progesterone only pill
What beta-hCG levels would you expect in ectopic pregnancy?
more than 1500
Investigations for ectopic pregnancy?
Pregnancy test kit first (positive) then trans-vaginal ultrasound.
Mum is fitting what do you give? she also has severe hypertension
Magnesium Sulfate bolus then infusion over 24 hours
Mum has high blood pressure what do you give?
labetalol if not then nifedipine
Features of Placenta Praevia?
Bleeding, pain, uterine tenderness, fetus lie, shock?, Ultrasound findings?
Red & profuse. No pain. No uterine tenderness. Abnormal lie - breech? Normal heart rate Shock consistent with blood loss Placenta is low.
Features of Placenta Abruption?
Bleeding, pain, uterine tenderness, fetus lie, shock?, Ultrasound findings?
Dark, sometimes absent. Pain is common & severe & constant Uterus - woody tenderness Lie is normal, distressed heart rate Inconsistent with blood loss. Ultrasound normal
Risk Factors for placenta praevia?
Smoking. Previous praevia Previous myomectomy or C-section High age High parity or large number of closely spaced pregnancy.
Risk Factors for Placenta Abruption?
PMH: pre-eclampsia or hypertension or abruption
smoking, increased age
IUGR
Complications of praevia:
Placenta Accreta (prevents separation) or precreta (penetrate through uterine wall)
IUGR
Premature delivery or death
Post-partum haemorrhage
Complications of abruption?
Placental insufficiency - fetal hypoxia and death
MUM: DIC, kidney failure, post-partum haemorrhage
Who gets anti-d, how much units, and when?
rhesus negative mums get 1500 units at 28 weeks and after any bleeding episodes and also after delivery if baby is rhesus positve
Complications of rhesus isoimmunisation?
Haemolysis leading to jaundice
hydrops fetalis and fetal death if severe.
jaundice and anaemia if mild
Risk factors for LGA
Previous LGA
Family Hx of LGA
High BMI mum
PMH: diabetes
Male infants