Obstetric Pharmacology Flashcards
How do you determine uterine blood flow?
(uterine aterial pressure - uterine venous pressure)/uterine vascular resistance
What are two most important drugs in the treatment of obstetric haemorrhages?
Oxytocin
Ergometrine
Does postpartum haemorrhage of >1500mL occur more with vaginal or caesarean birth?
Caesarean
Why is magnesium sulphate used in preeclampsia?
The treatment and prevention of seizures
How does maternal HR change during pregnancy?
Increases by 15-20%
How does maternal stroke volume change in pregnancy?
It increases by 30%
What are the functions of the placenta? (TIME)
T - transport of substances, gases, nutrients, waste products and drugs
I - Immunological
M - Metabolic (inc. inactivation of drugs)
E - Endocrine
What is labetalol used for?
Competitive non-selective Beta-adrenoceptor antagonist and competitive alpha1-adrenoceptor antagonist for hypertension
What is the greatest cause of maternal mortality in the developed world?
Cardiac Disease
How does maternal TPR change in pregnancy?
It decreases by 15%
What is the definition of preeclampsia?
Complicated hypertension in a pregnant woman that resolves by 3/12 postpartum
Why does hypertension occur in the mother in pregnancy?
To maintain perfusion to the foetus
How does maternal MAP change during pregnancy?
Drops by 15mmHg
