OB Path 3: Uterine Sq Cell Cancer and Breast Cancer

Question 1

signs of maturation in uterine epithlium

Answer 1

flattening and clear cytoplasm (due to glycogen storage)

Question 2

epidemiology of TNBC

Answer 2

blacks, younger, obese

Question 3

pathogenesis of TNBC

Answer 3

86% have p53 mut
20% have BRCA (*70% of BRCA pts will have TNBC)
others are germline and somatic mutations

Question 4

Where does TNBC commonly met to?

Answer 4

brain, lung, and liver, and distant LN

NOT USUALLY BONE

Question 5

irregular lumens (often slit line and peripheral)

Answer 5

usual ductal hyperplasia

Question 6

regular lumens

Answer 6

atypical ductal hyperplasia

Question 7

basal like morphology

Answer 7

TNBC

Question 8

small uniform, evenly spaced cells with well defined boarders in a cribiform pattern

Answer 8

atypical ductal hyperplasia

Question 9

when it presents it is usually at a higher stage and grade

Answer 9

TNBC

Question 10

CK 5/6 +

Answer 10

TNBC

Question 11

bridges (often stretched and twisted)

Answer 11

usual ductal hyperplasia

Question 12

ridged bridges

Answer 12

atypical ductal hyperplasia