Male Pathophys 2 (Handorf)

Question 1

most common germ line cell tumor (in pure form)

Answer 1

seminoma

Question 2

produces hCG

Answer 2

choriocarcinoma

Question 3

produces AFP

Answer 3

yolk sac tumor

Question 4

grossly homogenous looking testicular tumor

Answer 4

seminoma

Question 5

tissue of tumor represents more than 1 germ layer

Answer 5

teratoma

Question 6

fried egg appearence histo

Answer 6

seminoma

Question 7

almost exclusively a germ cell tumor of infants and children up to 3 years

Answer 7

yolk sac (also produces AFP)

Question 8

anaplastic looking cells under micro

Answer 8

embryonal carcinoma

Question 9

mimics the histo of placenta

Answer 9

choriocarcinoma

Question 10

germ line tumor that is characteristically necrotic and hemorrhagic? not necrotic or hemorragic?

Answer 10

embryonal carcinoma is hemorrhagic and necrotic

seminoma is not hemorrhagic or necrotic

Question 11

Schiller–Duval body

Answer 11

yolk sac tumor characteristic histo finding

Question 12

mets of this tumor bleed very easily bc it is a very vascular tumor

Answer 12

choriocarcinoma

Question 13

cysts are common with what type of germ cell tumors?

Answer 13

teratomas

Question 14

in what prostate zone does BPH arise?

Answer 14

central: transitional and periurethral zones

Question 15

in what prostate zone does prostate cancer arise?

Answer 15

peripheral zone

Question 16

what does the prostate produce

Answer 16

seminal fluid

Question 17

what does the prostate encircle?

Answer 17

neck of the bladder

Question 18

what type of epithelium does prostate have?

Answer 18

luminal and basal

Question 19

what cells of the prostate express PSA

Answer 19

luminal epithelial cells

Question 20

what is PSA

Answer 20

serine protease that liquifies seminal fluid coagulum

Question 21

stains with P63

Answer 21

basal epithelial cells of the prostate

Question 22

what are common causes of acute prostate inflammation?

Answer 22

E. coli, chlamydia, gonorrhea

Question 23

what drives BPH

Answer 23

androgens

Question 24

what cells are hyperplastic in BPH

Answer 24

prostatic glands and stroma

Question 25

how can BPH lead to death?>

Answer 25

causes blockage, get a UTI, become septic and die

Question 26

BPH is (nodular or diffuse)

Answer 26

nodular

Question 27

symptoms of BPH relate to

Answer 27

bladder obstruction and urinary stasis

Question 28

what is the characteristic color of prostate carcinoma

Answer 28

pale yellow

Question 29

how is prostate carcinoma diagnosed?

Answer 29

digital rectal exam or PSA elevation

biopsy is essential (use transrectal needle biopsy)

Question 30

in what common conditions will you see a rise in BPH?

Answer 30

prostatitis, BPH, prostate cancer

Question 31

age of men that have the greatest screening benefit

Answer 31

55-69

Question 32

how frequently should men be screened?

Answer 32

every 2 years

Question 33

at what age does prostate cancer screening stop

Answer 33

70

Question 34

prostate carcinoma like to invade what structures

Answer 34

nerves

Question 35

What is the Gleason Grading systme

Answer 35

look at histo of prostate carcinoma to determine grade/prognosis

Question 36

describe prostate carcinoma mets

Answer 36

in bone and are osteoBLASTic (bone FORMING)

Question 37

signs/symptoms of prostate carcinoma mets

Answer 37

anemia and bone pain