OB 5 Flashcards
- Rh+ means what?
- Rh- means what?
- Rh incompatibility is referred to as what?
- Rh+ = D antigen is present
- Rh- = D antigen is absent***
- Alloimmunization (maternal immune system exposed to Rh+ RBC from fetus. Incidence ↑ w/ subsequent pregnancies)
Rh antigens can cross placenta freely. Rh- mother develops antibodies to the Rh+ antigens. Maternal antibodies do what?
Maternal antibodies cross the placenta and fetal RBC hemolysis occurs (causes fetal death)
What is the method of prevention for Rh- moms?
RhoGAM is Rh immunoglobulin which attaches to Rh+ antigen and prevents mother’s immune response
RhoGAM is only administered to mother who are not what?
Alloimmunized (maternal immune system already exposed to Rh+ RBCs)
When is RhoGAM given?
1st dose: 28 weeks (prophylaxis)
2nd dose: within 72 hours of delivery of Rh+ infant
Or… at time of:
- Amniocentesis
- Ectopic pregnancy
- Spontaneous or induced abortion
- Bleeding during pregnancy
What are the 2 main risks to the fetus w/ Rh Incompatibility?
- Anemia
- Hyperbilirubinemia
Hemolytic Disease of the Newborn
Erythroblastosis Fetalis (Anemia) d/t Rh Incompatibility
Edema, cardiac failure
Severe and often fatal in utero
Hydrops Fetalis (anemia d/t Rh Incompatibility)
Toxic levels of unconjugated bilirubin
Kernicterus (hyperbilirubinemia d/t Rh Incompatibility)
Physiologic Jaundice of newborn
Hyperbilirubinemia (d/t Rh Incompatibility)
How should you manage maternal alloimmunization?
As a PA you will not manage these patients. REFER to perinatologist!
They will follow maternal anti-D titers to assess risk for Hemolytic Disease of Fetus or Newborn (HDFN)
What is the tx for Hemolytic Disease of Fetus or Newborn (HDFN)?
Intrauterine Transfusion
Early delivery
Which type of breech?
- Both hips flexed with knees extended so feet are adjacent to head (50 -70%)
Frank Breech
Which type of breech?
- Both hips and knees are flexed (5 -10%)
Complete Breech
Which type of breech?
- One or both hips are NOT completely flexed (10 – 40%)
Incomplete Breech