Cervix 1 Flashcards
Cystic structure that forms when columnar epithelium is covered by squamous epithelium
Glandular material becomes retained
What is this?
Nabothian cysts
Appear as translucent or yellow
Range in size from millimeters to 3cm
Benign
Asymptomatic – seen during speculum exam
Clinical px of what?
Nabothian cysts
is excision required for nabothian cysts?
NO
Etiology is unknown but may be due to chronic inflammation of cervical canal
what dz?
cervical polyps
Usually < 3cm
Benign
May cause post-coital bleeding or abnormal uterine bleeding
What dz?
cervical polyps
tx for symptomatic cervical polyps pts
polypectomy
what kind of tissue is he ectocervix made of?
stratified squamous epithelium
what type of tissue is the transformation zone made of?
Squamo-columnar junction
Metaplastic squamous epithelium
what kind of tissue is the endocervical canal made of?
single layer of mucin-producing columnal cells
describe adequate sampling of cervix
requires presence of endocervical sampling
how does HPV enter the body?
The virus enters the cervical epithelium through microlacerations that occur during intercourse.
HPV Pathophys:
The ___________ is very susceptible to the virus vs. squamous tissue.
The TZ/metaplastic tissue is very susceptible to the virus vs. squamous tissue.
what layer does HPV affect first?
infects basal layer first and only locally infects neighboring cells
can the HPY virus remain latent?
YES; The virus can remain latent for months to years until the host immune system no longer can successfully suppress the virus or poorly understood co-factors are present.
Mature___________ cellscontaining viral HPV migrate away from the basement membrane toward the surface.
Mature basal epithelial cells containing viral HPV migrate away from the basement membrane toward the surface.
what are the 2 main HPVs that are responsible for progressing to cervical cancer?
16 & 18