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Patho - Exam 2 > O2 Transportation > Flashcards

O2 Transportation Flashcards

1
Q

generating blood cells

A

Hematopoiesis

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2
Q

generating T, B, NK cells

A

Lymphopoiesis

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3
Q

iron transport molecule

A

Ferritin

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4
Q

Erythropoieten is excreted by the kidneys and acts on the bone marrow as negative feedback of RBC production

A

Erythropoiesis

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5
Q

Macrophages in liver: damaged/old RBC > hemoglobin> heme> biliverdin > bilirubin > waste bilirubin in feces, recycle heme/globin in the body to the red bone marrow

A

Hemoglobin degradation

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6
Q
A

Red cell metabolism

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7
Q

binding strength of oxygen to hemoglobin changes based on the environment

A

Affinity

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8
Q

More affinity, give away less oxygen, increased pH (basic), decreased CO2, decreased temperature

A

Left shift

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9
Q

Less affinity, give away more oxygen, decreased pH (acidic), increased CO2, increased temperature

A

Right shift

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10
Q

Bicarbonate ion (75%), carbaminohemoglobin (20%), dissolved CO2( 5%)

A

Carbon Dioxide Transport

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11
Q

May function as positive feedback (anemia, hypoxia > stimulates the production of RBC)

A

Erythropoiesis

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12
Q

Hypochromic (pale), microcytic (small)
MCV(volume)/MCH(hemoglobin)/MCHC(concentration) = decreased
ferritin = decreased, TIBC(total binding iron concentration) = increased
GI bleeding (men), menorrhagia (women)

A

Iron-deficiency anemia

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13
Q

Macrocytic (big cells)
pernicious (autoimmune) anemia
MCV(volume)/MCH(hemoglobin) = increased
MCHC(concentration) = normal

A

B12/folate deficiency

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14
Q

MCV(volume)/MCH(hemoglobin)/MCHC(concentration) = normal
RBC count = decreased
Burr cells

A

Chronic kidney disease anemia

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15
Q

Genetic mutation leads to deficient synthesis of globin chains (unable to make globin proteins)
Hypochromic, microcytic
MCV(volume)/MCH(hemoglobin)/MCHC(concentration) = decreased

A

Thalassemia

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16
Q

Glutamic acid error in the beta chain

A

Sickle Cell anemia

17
Q

Fragile, abnormal shaped cells

A

Hereditary spherocytosis

18
Q

Not immediately detectable on CBC as it relates to fluid shifts/concentration differences

A

Acute blood loss

19
Q

Asymptomatic
Pallor, fatigue, loss of stamina, weakness, tachycardia, exertional dyspnea, orthostatic hypotension, dizziness, syncope

A

Clinical manifestions of anemia

20
Q

Relative: dehydration
Primary (P. Vera): RBC hyperplasia, increased blood viscosity
Secondary: increased RBC production due to chronic hypoxia

A

Polycythemia (too many blood cells)

21
Q

Visual disturbances, dizziness, claudication, stroke, MI

A

Hyper-viscosity syndrome

22
Q

Idiopathic myeloproliferative disorder
RBC hyperplasia, increased blood viscosity
Hypertension, thrombosis, hemorrhage, hematomegaly, night sweats

A

Polycythemia Vera

Patho - Exam 2 (10 decks)

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