Nutrient utilization Flashcards

1
Q

Well child nutrient utilization

A

“basal” needs - respiration, metabolism staying alive
+/- physical activity
Thermic effect of food - energy required to break down food (~10%) of intake
Growth: huge in infants

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2
Q

Sick child nutrient requirements

A

increased basal needs: High T, HR, RR, increased demand for ATP
reduced physical activity
reduced/no growth

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3
Q

physiology of stress

A

Burns/Sepsis/Surgery/Trauma
–> stimulation of CNS

ADH: water retention
Catecholamines: Renin, glucagon released
–> hyperglycemia, lypolysis, sodium retention
ACTH: glucocorticoid –> proteolysis, gluconeogenesis

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4
Q

ACTH effects

A

stimulated by CNS during stress
stimulate hepatic protein synthesis of acute phase reactants
stimulate catabolism of muscle –> aa for gluconeogenesis
Alanine (from muscle) stimulates glucagon

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5
Q

Catecholamine effets

A

stimulate glycogenolysis in muscle
stimulate gluconeogenesis from aa
decreased insulin relative to glucagon, insulin resistance –> hyperglycemia

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6
Q

Fasting state

A

cortisol stimulates muscle breakdown
cortisol, glucagon, epinephrine stimulate glucose production
aa are primary source of glucose
very large urinary nitrogen loss

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7
Q

Starvation state

A

fuel shift from aa –> fat
spares protein for vital functions
fat oxidation: glycerol (glucose) + FFA (energy)
incomplete fat oxidation –> ketone body formation for CNS, body

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8
Q

Protein turnover

A

increased in stress

reduced in starvation

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9
Q

Insulin during stress

A

increased to block lipolysis

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10
Q

Insulin during starvation

A

reduced to promote lipolysis

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11
Q

Nutrients needed in sick child - helpful

A
Fe
P
Mg
Vitamin C, D
folate
B12
Se
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12
Q

Adolescence

A

WHO: 10-19
Period of rapid growth second only to infancy
nutrient requirements high, greatest during peak growht period, especially high for those who are very active
achieve final 20% of adult height and 40% of adult skeletal mass
Physical and sexual maturation
prevention of lifestyle disease

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13
Q

Peak height velocity - boys

A

longer childhood growth

higher peak velocity

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14
Q

Peak height velocity - girls

A

2-3 y before boys

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15
Q

Growth spurt

A

6 y in boys

4 y in girls

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16
Q

Weight growth in adolescence

A

boys: peak height velocity coindcides with peak weight velocity
Girls: peak weight velocity 6-9 mo before peak height velocity

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17
Q

Pre-pubertal/adult fat % in boys/girls

A

Pre-pubertal: 15%
Men: 15%, lean mass doubles btw 10-17
Women: 23%

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18
Q

Girls Fe requirements

A

9-13: 8 mg
14-18: 15 mg (11.4 OCP)
+1.1 if in growth spurt
+2.5 if menstruating

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19
Q

Boys Fe requirements

A

9-13: 8 mg, +2.9 if in growth spurt

14-18: 11 mg

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20
Q

Fe requirements during adolescence considerations

A

Vegetarian: multiply by 1.8 to correct for non-heme Fe

Upper level of iron - 45 mg/d based on GI side effects

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21
Q

Semi-vegetarian

A

no red meat

22
Q

Pesco-vegetarian

A

will eat fish

23
Q

Lacto-ovo-vegetarian risks

A

may be at risk for energy, protein, iron, zinc

24
Q

Vegan risks

A

at risk for energy, protein, iron, zinc, B12

25
Anorexia N, restricting type
During last 3 mo, individual has not engaged in recurrent episodes of binge eating/purging Weight loss primarily due to dieting, fasting, and/or excessive exercise
26
Anorexia N, binge-eating/purging type
During last 3mo, individual has engaged in recurrent episodes of binge eating/purging
27
Age of onset of anorexia nervosa
early to mid adolescence common, but can occur at any age even in childhood Primarily seen in girls, but boys are seen more frequently in childhood year
28
Boys with anorexia nervosa
shape is more of an issue than weight concern around preventing development of a flabby shape exercise predominates small number, but increasing
29
Bulimia nervosa
``` Binge eating + extreme wt loss compensatory behaviours (purging/laxative/diuretic, fasting, exercise) at least once a week for 3 mo self evaluation unduly influenced by body shape + wt can be normal or overweight salivary gland enlargement enamel erosion esophagitis arrhythmias blood abnormalities (electrolytes, amylase, etc) finger/back of hand may have callus diarrhea/constipation edema in ankle ```
30
Bulimia nervosa age of onset
Later adolescence and young adulthood
31
Eating disorder in partial remission
full criteria was met, but currently no longer fully meets all criteria
32
"Eating disorder in full remission
full criteria was met, but now none of criteria has been met for a sustained period of time
33
Binge eating disorder
regular/sustained binge eating episode | characterized by both eating in a discrete period of time and a sense of lack of control over eating during episode
34
Binge eating disorder age of onset
young adulthood/midlife disorder | more even gender distribution
35
Avoidant/restrictive food intake disorder
ARFID new category is like anorexia nervosa except without body image disturbance or weight/shape overvaluation
36
Other Specified and Unspecified Feeding and Eating Disorder
OSFED, UFED, new terminology Atypical anorexia nervosa: BMI normal Purge disorder: sub-threshold forms of Bulimia Nervosa + binge eating disorder on basis of insufficient frequency or duration of ED behaviours
37
Anorexia effect on NS
``` can't think right fear of gaining weight sad, moody, irritable poor memory fainting changes in brain chemistry ```
38
Anorexia effect on skin, connective tissue
``` thin and brittle hair weak muscles, swollen joints, fractures, osteoporosis easy bruising, dry skin growth of fine hair all over body cold intolerance yellow skin brittle nails ```
39
Anorexia effect on CV system
``` Anemia low BP slow HR palpitations heart failure ```
40
Anorexia electrolyte disturbances
Low K, Mg, Na
41
Anorexia effect on GI/GU
constipation bloating kidney stones kidney failure
42
Anorexia hormonal changes
``` Amenorrhea bone loss problems growing infertility higher risk for miscarriage higher risk for C-section baby with low birth weight post-partum depression ```
43
Bulimia brain and behavioural changes
``` depression fear of gaining weight anxiety dizziness shame low self esteem fatigue ```
44
Bulimia soft tissue/muscle/bone changes
Cheek swelling, soreness Mouth: cavities, tooth enamel erosion, gum disease, sensitive teeth Throat: sore, irritated, can tear and rupture, blood in vomit Abrasion of knuckles, dry skin
45
Bulimia CV changes
``` Arrhythmia heart muscle weakened heart failure low pulse low BP anemia, fatigue ```
46
Bulimia GI/GU changes
``` Problems from diuretic abuse Dehydration, low K, Mg, Na Ulcers, pain, can rupture, delayed stomach emptying Constipation irregular BM bloating, diarrhea, cramping ```
47
Bulimia hormonal changes
irregular/absent period
48
Consequences of eating disorders
Most changes are reversible EXCEPT: - bone density after a certain age - growth stunting - catch up growth can sometimes occur but may not be enough - brain changes not completely reversible, but consequences unknown - enamel erosion
49
Eating disorder - criteria for urgent admission
Physiological instability: - postural hypotension - >20 mm Hg systolic - resting bradycardia
50
Other reasons for admission due to eating disorders
Growth arrest and pubertal delay with poor weight gain in outpatient tx (esp for younger adolescents) failure of outpatient tx patient/parent not coping at home lack of local services
51
Medical reasons for admission in eating disorders
Refeeding syndrome can happen in severely malnourished patients True phosphate deficiency manifests after 2-3 d of adequate nutrition Requires close observation, regular blood tests and ECGs with phosphate tx, monitoring
52
Clinical points in managing patients w/ eating disorders
Correct existing deficiencies, including fluid Correct vol depletion, check renal function measure K, Phosphorus, Mg daily, correct deficiencies Calories: start where the intake is, increase q2-3d until at least 2000cal/D or more MONITOR!