Nutrient specifics Flashcards

1
Q

Vitamin A

A

Large amounts in: Beef liver, spinach, carrots (raw), squash/sweet potato

Lesser amounts in: Boiled egg, dairy, herring, fortified cereal

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2
Q

Vitamin K

A

Large amounts in: Oils (e.g. sunflower/safflower oils) and their seeds, dark green leafy veg + broccoli and sprouts, dried prunes

Lesser amounts in: Herbs and spices

Spicy PODS
Prunes, Oils, Dark, Sprouts
H&S

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3
Q

Hyperlipidaemia prescription…

What studies underpin the evidence?

A

Increase:
Portfolio diet - almonds, sterols/stanols, viscous fibre
Fibre (40-45g)
Beneficial MUFA (canola, peanut, avocado, olive, nuts) and PUFAs (omega 3s - found in oily fish, flax/chia/hemp) in place of SF/TF

Decrease:
Saturated fat - AHA/ACA guidelines 5-6% total calories
Trans fats - eliminate
Free fats

Studies:
Portfolio diet - Jenkins 2003
Orlich - Lifestyle heart trial, sorta
Adventist 2 - stepwise decrease in lipids in different diets

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4
Q

Iron sources (plant based)

What aids apsorption?

A

High sources - lentils/chickpeas/beans/quinoa, tofu, cashew/chia/pumpkin, dried apricots/figs/raisins, dark green leafy veg - kale/spinach

Vit C aids absorption

Easy way to remember - all the dried whole foods in my cupboard (fruit and legumes)

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5
Q

Vitamin C

A

High sources (all the Cs) - citrus, cantaloupe (and tropical fruit), cabbage and associated (sprouts, broccoli, boy chow), cauliflower

Less high sources - other fruit and veg

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6
Q

Calcium

Special considerations

A

High sources - dairy, calcium fortified juices and plant based milks, TOFU, CHIA

Less high sources -almonds, low oxalate dark green veg

High oxalate veg such as spinach, chard and beet greens limits calcium absorption

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7
Q

Vitamin D

A

High sources - fortified milks etc, oily fish

Less high sources - dairy, fortified marg, egg, fortified cereal, beef liver

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8
Q

Magnesium

A

High sources - dark chocolate, brazil nuts, cashews, almonds

Less high sources - Tofu, beans, wholegrain, meat and dairy

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9
Q

Vitamin E

A

High sources - Sunflower/safflower, almonds and hazelnuts (seed oils and nut milks)

Less high sources - peanuts, avocado, and spinach/brocolli (dark leafy greens) (spreads and sides - guacamole)

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10
Q

Potassium

A

High sources - potato, sweet potato, squash, banana, plantains, beans/peas

Less high sources - diary, fish, poultry, veg in general

(Carribean stew - with a healthy protein and veg)

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11
Q

4 types of saturated fat:
What are the two most common?
What are their sources?
What are their effects?

A

Lauric acid

  • mainly coconuts, also palm kernel (not palm) oil, a little in dairy
  • raises HDL and LDL
  • may cause heart disease

Steric acid (second most common)

  • animal fats, dark chocolate
  • Lowers LDL
  • Increases colorectal cancer and endothelial damage

Palmitic acid (most common)

  • palm oils, as well as meats and dairy
  • harmful, increases LDL
  • heart disease

Mystiric acid

  • palm oil, coconut oil, dairy
  • biggest raiser of cholesterol, also raises trigs, possibly HDL
  • increased heart disease
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12
Q

Where does sugar come from?

A

Fizzy drinks 47%
Snacks and sweets 31%
Desserts

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13
Q

Where does saturated fat come from?

A

One source : Cheese and pizza

Other source : 
Burgers 19%
Snacks 18%
Protein foods 15%
Dairy 13%
Condiments 7%
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14
Q

Where does sodium come from?

A
Mixed meals 44%
Protein foods 11%
Grains 11%
Tomatoes/potatoes 11%
Sweets 8%
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15
Q

Where do transfats come from?

A

Grain based processed foods 40%
Animal products 21%
Margerine 17%

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16
Q

Where does cholesterol come from?

A
Eggs 24.6%
Chicken 12.5%
Beef 11%
Cheese 4.2%
Pork 3.9%

All the major proteins

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17
Q

Fibre - guideline amounts?

Soluble:

Insoluble sources:

A

25/38g, better 40/45g

Fruit Legumes Oats Soluble (FLOwS)

Veg Seeds Wheat Insoluble Bran (Very SWIB)

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18
Q

What did the EPIC study show about diabetes?

A

EPIC study: each 5% calories from animal protein gives 30% increased diabetes risk

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19
Q

What did the combined NHS1/2 and HPFUS show about diets and diabetes?

What other outcome did they look at?

(regarding healthy and unhelath PB diets)

A

A health plant based diet reduces diabetes risk by 34%, whilst unhealthy PB increases by 16%
(are these the same numbers as the Pan et al substitution studies?)

CAD: 0.92 overall, 0.75 healthy, 1.32 unhealthy
DM2: 0.67 healthy, 1.16 unhealthy

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20
Q

What did the NIH study into nutrition in diabetes show?

What did it compare?

Broad outcomes?

A

It compared a plant based diet with the ADA advised diet

Plant based diets gave 3 x reduction in HbA1c, 2 x reduction in LDL, decreased weight and meds

4 findings, 3/2/1/1
aka 4/3/2/1/1

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21
Q

Mechanisms of endothelial injury? (3)

What is TMAO?

What outcomes does TMAO associate with?

A

Diminished nitric oxide
Diminished progenitor cells
Increased TMAO

TMAO produced by bacterial metabolism of choline (internet) and lectin/pectin (book).
These bacteria are more present in regular meat eaters.

TMAO levels associated with all-cause mortality and cardiovascular disease/atherosclerosis

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22
Q

The mixed evidence on dairy…

What benefits are there to dairy?
What about yoghurt?
What about plant based milks?

In who does milk help bone health? by how much?

A

Dairy weakly helps CVA and heart disease…
Yoghurt helps DM
Plant based alternatives probably much better

Milk improves bone health in children and women.
Bone mineral density increases of 0.7-1.3%

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23
Q

Breast cancer - obesity and lifestyle…

A

You can be obese or non-obese - same mortality if physically active and getting your fruit and veg!

180 minutes and 5 F&V

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24
Q

Weight and diet:

What difference do calories make?

Whole food plant based diets, do they cause weight loss?

Do adults or children having sugary drinks result in weight change?

A

If the calories are the same, no evidence that weight will change.

Yes they do!

Adults yes, children no

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25
Q

The EPIC study:

Population number
Follow up length

BP findings (3)

Bone health (2)

Cancer (3)

All-cause (1)

Heart disease (1)

4 behaviours and how much years of life?

A

500000 European adults
>10 years

Blood pressure:
Low sodium and high potassium, fruit and veg

Bone health and bone fractures
Physical activity with high impact activity

Cancer:
Obesity - increases a number of cancers
Fibre - reduces colorectal
Sex hormone and fat intake - increases breast cancer

All cause death
Increases in eating fruit and vegetables

Heart disease
High blood sugar levels

14 years of life gained from 4 behaviours:
not smoking
being physically active
moderate alcohol intake
five fruit and vegetable servings a day
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26
Q

The exercise tolerance tests…

If <30%

If >70%

In between?

A

<30% - symptom limited ECG

> 70% - angiography

in between either MRI or 12 minute tolerance test

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27
Q

Epidemiology of diabetes:

How many diagnosed in US, how many undiagnosed?

How many pre-diabetes?

Whats the costs - direct and indirect?

WW prevalence and US prevalence?

A

23 million diagnosed, 7 million undiagnosed
80 million pre-diabetes

Costs: total 300bn 230bn + 90bn

8.5 and 9.3%

Ways to remember:
Costs overall the same as smoking (300bn with 150/130 split)
30ml and 300mil
23 diagnosed and 230 direct
7mil undiagnosed, 80pre-d, 90 indirect costs

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28
Q

Positive psychology - the 5 pillars

A
Positive emotions
Engagement
Relationships
Meaning
Accomplishments
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29
Q

Sleep restriction study and food seeking behaviours:

What did they do?
What did they seek - calories and type?

A

4 hours for 5 nights

300 calories, saturated fats

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30
Q

Obesity counselling:

4 important CBT techniques:

A

4 techniques:

  • self monitor
  • goal set
  • normalise healthy diet
  • problem solve
MNOP
Monitor
Normalise
gOal set
Problem solve
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31
Q

What do physicians with increased empathy produce? (number please)

How long do they need training for?

What else does the patient provider relationship affect? (3 things)

What are the two key asepcts of behaviour change?

A

Much better HbA1c (56% vs 40%)

10 hours sufficient

HTN, BM and function

(trust in provider is one of the key aspects of behaviour change, as well as having a good support system)

32
Q

FLEXIBILITY guidelines

A

Adults - 10 mins, 2-3 times a week (but daily is best)
10-30seconds per stretch, 60 total, 2-4 reps

For older adults it is the same but 30-60s per stretch

33
Q

BALANCE guidelines

A

Adults 20-30min 2-3 days a week

Older 1 hour, 3+ days a week

34
Q

Patient provider interaction systematic reviews:

Which 3 interactions were looked at?

A

1) Patient activated
2) Provider enhanced
3) combination

22/30 - intervention altered the interaction
11/25 improved health outcomes
5/25 worsened

Health outcomes overall poorly assessed

35
Q

Esselstyn

Diet and aim of diet

A

Low fat 10%, no oils, WFPB
Aim of cholesterol <150mg/dL
Statins individualised

24 patients

5-year experience
6 non-adherent released to standard care in 12-18 months
18 adherent - by 5 years
1) 11 had angiography - 100% disease arrest, 73% (8) reversal
2) 9 had angina - 2 stopped, 7 improved
3) 1 died after angio, having had disease reversal, post mortem showed no MI
4) Cholesterol went from 237 to 137

at 12 years:

  • 1 further became non-adherent
  • Mean cholesterol 147
  • no extension of clinical disease, no coronary events, and no interventions.
  • original compliant 18 participants experienced 49 coronary events in the 8 years before the study
  • Non-adherent had 13 events
36
Q

DASH for hypertension

Patient group and numbers?

Interventions and control?

What wasn’t changed?

Results:
Baseline mean BP
Changes by group (compared to control)?

How many had hypertension?
What did combo do?

A

n=459, SBP<160, DBP 80-95

3 weeks of US diet THEN:

1) continue US diet
2) High F&V diet
3) Combination diet - high F&V, low fat dairy, low sat fat and total fat

Sodium and body weight maintained

Baseline 131/85
F&V decreased 2.8/1.1
Combo 5.5/3

326 had hypertension
Combon decreased 11.4/5.5

(Note 1.1 and 5.5 vs 11/5.5 for HTN group)

37
Q

DIETFITS trial

What diets were compared?

What follow up?

What findings?

  • weight loss
  • other (2) significant associations
A
  • Low fat versus low carb

12 months

FINDINGS:
Low fat wt loss 5.3kg
Low car 6.0kg

Adherence key, neither INS30 nor the 3 genotypes

38
Q

Epigenetic studies:

Dutch winter hunger - what conditions were affected (4)

A

obesity
schizophrenia
fertility
finger print

39
Q

Epigenetic studies:

How does hyperglycaemia affect it (a specific promotor region)

A

The NFkB p65 promotor (3 genes…)

Remember NfKB is ‘key’ in diabetes - hyperglycaemia affects it

PGC-1 is a key epigenetic aspect of DM2 susceptibility

RXRA methylation affected in pregnancy

40
Q

Epigenetic studies:

Agouti mice

A

Genes can be changed by lifestyle

41
Q

Epigenetic studies:

What promotor region is affected by maternal diet?

What does this affect?

What aspects of a plant based diet are important in this?

A

RXRA promotor methylation

Genes associated with adiposity and metabolic syndrome

Methyl and B vitamins in a plant based diet

42
Q

What epigenetic changes does exercise induce?

A

GLUT4 expression in skeletal muscle

However, no change in microvascular risk in 5 years

43
Q

What epigenetic gene is important in diabetes type 2 susceptibility?

A

PGC-1

44
Q

Epigenetic

4 affectors
4 positives
4 negatives

A
Affectors:
Sleep
Diet
Physical activity
Obesity
Positives:
Polyphenols and B vits
Exercise
Low stress
Maternal and paternal diet
Negatives
Sugar
Alcohol
Sat fat
Processed food
45
Q

The microbiome and fibre - what’s the importance?

What does the important thing do? (5)

A

Butyrate, a SCFA, is produced by bacterial metabolism of viscous fibre.

5 benefits

1) Insulin sensivity
2) Mineral absorption
3) Lower cholesterol and trigs
4) Lower hepatoglycolysis
5) Increased satiety

2 blood sugar 3 others

46
Q

Adiponectin - 3 benefits!

2 things that inhbiit/reduce it

A

1) clears trigs
2) reduces TNFa
3) protects endothelium

FFAs and inflammation

47
Q

Insulin resistance

What happens as a result of adipocyte hyperplasia/trophy?

Whats happens from the NFkB pathway?

A
  • release 3 mediators
    1) leptin - pro-angiogenic, cytokine release, apoptosis,
    2) RBP - prevents activation of glucose binding proteins, 3) EDF - causes IR)
  • cause exogenous adipose tissue (liver/muscle)
  • cause inflammation (TNFa, JNK, NFkB, CRP, IL6, MCP1, PAI1)
  • greater lipolysis - therefore TAG, DAG, free fatty acids (inflammatory)

NFkB activates telomerase, cytokines, adhesion molecules, VEGF and TNF. Also results in macrophage recruitment.

NOW That Cat Attached My Violet Turtle

48
Q

Beta cell death

A
Dyslipidaemia - VLDL/LDL --> apoptosis
Glucotoxicity --> apoptosis
Cytokines - NFkB/JNK --> macrophages
Oxidative stress - FFA, BM, NFkb/JNK
Leptin - cytokines, apoptosis, proangiogenic
49
Q

How much have the following increased?

Sugar intake

Oil intake

Chees intake

TV

A

Sugar - 63.5kg/year

Oil - 41.7kg/year

Cheese - 11.3kg/year

TV from 0 to 4 hours a day

50
Q

Hypertension nutrition advice:

Increase

Decrease

A

Increase:
K+, Ca2+, Mg2+
Fibre/fruit and veg

Decrease:
Sodium
Saturated fat
Caffeine
Alcohol - J shaped curve
51
Q

Breast cancer and diet - 2 studies:

Women who were their own crossover:

Women who were overweight, normal or obese:

A

1) 12 women, 2 weeks control and 2 weeks exercise and diet intervention decreased cancer growth, IGF1 and increased IGF1BP
2) 1490 women - if you ate 5FV and 180PA you have 50% RR mortality independent of weight category

52
Q

Anderson showed what about plant based diets and insulin use?

A

in 16 days - 11 stopped insulin and 9 decreased without weight change

53
Q

Dietary prescription for cancer:

What are the aims?

Avoid what foods?
Increase what foods?

A

1) Support the immune system
2) Provide low inflammatory/antioxidant state

Avoid inflammatory foods:
Processed grains, sugar
Red and processed meats
Saturated and transfats

Increase:
Fibre and antioxidants

54
Q

Antioxidant list from the ‘cancer’ section:

A
Beta carotene - in carrots and yellow/orange veg
Lycopene - in tomatoes
Resveratrol - in grapes and blueberries
Selenium - in mushrooms and brazil nuts
Vitamin C and vitamin E

Resveratrol - sounds like petrol - the smell of a good wine

55
Q

Tobacco costs?

A

130bn direct, 150bn in lost productivity

56
Q

Human cost of tobacco?

What is tobacco number 1 for?

A

CDC states it is the number one cause of preventable disease and death - Cleveland clinic in 2017 say that obesity may have overtaken

57
Q
From smoking:
How many die prematurely every year?
How many suffer from disease caused by smoking?
Smokers lose how much LE?
Smokers are more likely to what?
A

50 million
16 million
lose 10 years
suffer health problems and disability

58
Q

Smoking and cancers

how many carcinogens in smoke?
how many linked cancers?
if nobody smoked, how many cancer deaths would not happen?

A

70 carcinogens
40+ cancers
1/3rd

59
Q

Smokers and US deaths:
What number?
What proportion of deaths?
What proportion of users?

A

480000
1/5th
1/2 will die from use

60
Q

What may nicotine be as addictive as?

A

heroin, cocaine, alcohol

61
Q

How many smokers want to quick %?

How many will manage without assistance?

A

68%

5%?

62
Q

Is there a dose-dependent effect in smoking cessation?

What does the most effective counselling involve?

A

yes - more intense, is better, with more than 4 person-to-person sessions being best

practical counselling involving problem solving an skills training, and social support

63
Q

USHHS recommendations on medications in smoke cessation?

What are the special populations with poor evidence (4)?

A

Recommends everyone uses except if CI or special populations with poor evidence

Pregnant, teenage, smokeless tobacco and light msokers

64
Q

How many FDA approved treatments are there for smoking?

A

5 NRT and 2 non-NRT

Off label is nortrip and clonidine

65
Q

Bupropion and varencyline MODA?

A

bupropion is a NA and DA rey-take inhibitor

Varencycline is a nicotinic receptor partial agonist

66
Q

What are the most effective smoking cessation treatments?

What 2 things are recent studies suggesting?

A

Varencyline and bupropion gives 71% at 12 weeks, and 58% at 6 months

Bupropion patch and lozenge are 54% at 8 weeks, whilst B and L is 50%

Recent studies suggest that NRT and varenicline may be effective without SE worsening, whilst V+B+NRT may be even better

67
Q

Smoking cessation in chronic disease or mental illness:

-what is recommended and what’s it’s success rate?

A

Triple threrapy - Bupropion, patch and another NRT

62% vs 37% with patch alone at 8 weeks

35% vs 19% at 6 months

68
Q

Weight gain and smoking cessation:
How much?
Who is most affected?
What delays it?

A

<10lbs
More common in women
Bupropion and NRT may delay but not prevent weight gain

69
Q

Specific mental illness and smoking cessation:

2 conditions and their recommendations

A

Bipolar - no bupropion - patch recommended

Schizoids - patch recommended

70
Q

How long can you use bupropion and vareniclin

A

B for 6 months

V for 12 weeks, twice in a year

71
Q

Smoking cessation:
2 treatments not effective
4 with limited evidence

A

Acupuncture and hypnosis

Physiologic feedback, restricted environmental stimulation therapy, use of incentives, cigarette fading

Also eCigs are not well evidenced

72
Q

Effective counselling in helping people quit:
2 principles
5 specifics

A

Should include problem solving skills/skills training and social support

1) Help recognise situations where they may be vulnerable to smoke
2) Develop coping skills
3) provide info about smoking and quitting
4) Provide support and encouragement, communicate care and concern
5) Engage in discussions about quitting

73
Q

5 As of tobacco cessation?

A
Ask
Advice
Assess (willingness to quit)
Assist (quit date within 2 weeks)
Arrange (FU within 3 days of quit date, then within 1month)
74
Q

Short model of tobacco cessation? 3As

A

Ask
Advise
Refer

75
Q

Coverage of smoking cessation counselling?

A

Medicaid - Individual>group>telephone covered

Medicare - 4 sessions per quit, 2 quits per year. Intermediate 3-10 minutes of intensive >10 minutes. Prescription drugs