More of everything Flashcards
Insulin resistance (/failure to produce enough insulin)
Adipocytes undergo hyperplasia and hypertrophy
This results in:
1) Overproduction and release of - leptin, retinol binding protein (prevents activation of glucose carrying proteins), EDGF (causes IR), inflammatory cytokines (e.g. TNFa, IL1/2), decreased adiponectin (that normal protects the endothelium), activation of the JNK and NFkB pathways
2) Muscle and hepatic fat deposition/TAG
3) Macrophages are recruited
4) Increased FFA in the blood stream - cause inflammation
Standard drinks
- what is one standard drink?
- how many drinks in standard bottles?
Standard drinks include:
12 oz beer, 5oz wine, 1.5oz 80 proof spirits
Bottles of: 750ml wine (5 drinks) 1L spirits (24 drinks) 750ml spirits (18 drinks)
Sleep hormones at different stages: Onset of sleep First half of sleep Second half of sleep Awakening
At onset - melatonin rises
First half - melatonin continues to rise, leptin produced throughout sleep
Second half - melatonin gradually falls
Awakening - cortisol spike shortly after, cortisol gradually rises through sleep too
Stages of sleep
How many are there? And what are they?
4 stages:
Stages 1-3 of non-REM sleep
REM sleep
Stage 1 - several minutes, going from awake to asleep - high amplitude theta waves, very slow
Stage 2 - deeper sleep, slow brain waves with some brief bursts ‘sleep spindles’
Stage 3 - deepest sleep, slow waves, makes you feel refreshed ‘delta sleep’ (previously stages 3 and 4)
Benefits of MBSR programmes?
Whats the ACRONYM?
MBSR really (h)RELPS
1) Physical symptoms and psych symptoms
2) Loneliness in the elderly
3) Empathy and compassion
4) Resilience/ability to cope with stressors
5) Self-esteem
Nurses health study - how much physical activity is found to reduce all-cause mortality? By how much?
And how much doesn’t give any significant benefit?
1-1.9 hours a week gave all-cause mortality of 0.82
Whilst >7 a week didn’t give significant improvements
Smoking quitting benefits? Immediate 1 year 2-5 years 10 years
Immediate - 50% risk of acute MI
1 year - 50% of heart disease
2-5 years - stroke at baseline levels
10 years - cancer at 50% (lung)
Physical activity:
What benefits of RR of all-cause morality at what hours of exercise (The simple chart and the longer chart…)
And for MeTs and years of life gained?
At what level of MeTs is ‘most benefit’ achieved?
Another random stat - 150 minutes reduces mortality how much? 7 hours how much?
All-cause mortality and hours of exercise a week:
- 8 = 1.5 hours
- 7 = 3 hours
- 6 = 6 hours
Longer chart:
- 0 = 30mins
- 8 = 90mins (1.5 hours, same as above)
- 73 = 180 mins (3 hours)
- 64 = 330 mins (5.5 hours)
- 615 = 420 mins (7 hours)
In terms of MeTs and years of life 0-3.75/week = 75 mins = 1.8 3.75-7.5 = 90-150 = 2.5 7.5-15 = 200 = 3 15-22.5 = 400 = 4 \+22.5 = 500 = 4.5
10-20Met hours!
19% and 24%
Assessing fitness in the different domains:
Functional assessment?
Cardiorespirtatory (3 tests)?
Function - 6 minute walk test, compare pre and post intervention
CR fitness:
1) the step test - 3 minutes of stepping to metronome, rest for a minute, then measure heart rate, compare to charts
2) the rockport test - run/walk a mile, measure heart rate and time
3) sub ventilatory threshold test - easiest on treadmill, increase exercise going up by 5% heart rate until breathing rate changes, can’t say 5-10 word sentences
Physical activity intensities…
What different tests are there?
What are their different thresholds?
What thresholds correspond to what MeTs?
For each: very light/light, moderate, vigorous
Talk test: can sing/can talk/can’t talk
Maximum heart rate %: 63% or less, 64-76%, 77% or more
Heart rate reserve %: <40%, 40-60%, >60%
MeTs: <3, 3-6, >6
Borg scale of perceived exertion
USPSTF and alcohol
Grade B recommendation to assess and give brief advice
Epidemiology of sleep…
What is the average amount of sleep?
How many young adults get less than what duration of sleep?
What percentage gets less than 6 hours?
How many people have difficulty sleeping?
What percentage seek help?
What is the cost?
Average sleep is 6 hours 57
37% get less than 7 hours
20% get less than 6 hours
60 million
10% (6million)
60 billion dollars
ALL THOSE NUMBERS ARE LINKED
Results of low daylight?
On melatonin suppression?
On other aspects of life?
- false blue light sensitivity
- decreased affect, mood, alertness and peak body temperature
The ACSM suggests how much exercise for obese patients?
250 minutes a week, with 60-90 minutes a day
Resistance twice a week
What is heavy drinking?
- NIAAA defines heavy alcohol use as more than 4 drinks on any day for men or more than 3 drinks for women.
- SAMHSA defines heavy alcohol use as binge drinking on 5 or more days in the past month.
I think the best for the course is exceeding 4/3 drinks in the past 30 days
Binge drinking and heavy alcohol use can increase an individual’s risk of alcohol use disorder.
Alcohol and the manual:
At what level do symptoms of impaired control develop?
What are the DSM thresholds for mild/mod/severe?
AUDIT thresholds and sensitivity?
- Mild-mod is characterised by impaired control
- 2-3, 4-5, 6+
- 5-10 20%, 10-15 40%, 16+ 90%
AGEs - two things that make it more likely that I always forget…
conditions associated?
more trace minerals, more acidic or alkaline pH
Atherosclerosis, renal disease, poor wound healing, DM1 and 2
Poor sleep and mental health.
What factor is decreased?
What does poor sleep do in different diseases? (5)
BDNF is lower
Poor sleep associated with worsened depression, SAD, anxiety, PTSD (worse if sleep deprived) and TBI (worse if sleep deprived pre or post)
Treating diabetes mellitus…
Bypass - what remission at what time periods?
18-24 months - 39-83% remission (with weight losS)
5 years and 15 years - 30%
Physical activity and cancers…
Which cancers have evidence?
What threshold of exercise duration?
What % risk reduction?
(note that physical activity also reduces CAD by 20-30% in primary prevention)
Colorectal - 3-4 hours a week, 17-30%
Breast - 3-4 hours a week, 20-30%, also prevents recurrence and benefits treatment/side effects/mortality
Prostate - physical activity during and post treatment improves quality of life, symptoms, survival and cardiorespiratory fitness
Nutrition and cancer links…
Breast
Fruit and veg, soy
Obesity, red and processed meat
Colorectal
Fruit and veg, fibre, calcium
Red and processed meat
Prostate
Selenium, lycopene, whole food plant based
Gastric
Fruit and veg, antioxidants
Processed meat
The nurses health study showed what percentage of diabetes type 2 was attributable to what behaviours?
It also showed what about:
Meat consumption
Egg consumption
91% due to PI, smoking, obesity, poor diet, alcohol intake
(similar to the finings on 5 healthy behaviours and coronary artery disease risk)
Have regular meat or 5 eggs a week increased diabetes risk
Diabetes and physical activity - how much physical acitivity is sufficient to decrease risk?
What % decrease occurs? what about accounting for BMI?
Meta-analysis of brief advice vs structured exercise and HbA1c - what did it show?
150 minutes a week
31% and 17%
BA only works if diet advice also given, however structured exercise programmes had some HbA1c benefit
The nurses health study and health professional follow up study - diet/substitutions of saturated fat and heart disease…
1) Study by Joshipura showed what about fruit and veg intake?
2) Study by Li Y showed what about quintiles, and what about dietary substitutions?
1) Each serving gave a 4% decreased risk
2) The top quintile of intake, vs the bottom quintile for PUFA had 20% decreased risk, WG had 10% decreased risk, sugar and refined grains had 10% increased risk
Substituing 5% of daily intake of calories of saturated fat with PUFA gave 25% decreased risk, MUFA gave 15% decrease, whole grain gave 9%, whilst refined grains and sugar didn’‘t change anything
The nurses health study and health professional follow up study - substitution analysis of red and processed meats by Pan 2012
1) Diabetes - what did it show about meat? What about substitutions of meat?
2) Mortality substitutions?
1) HR for 1 serving of red meant is 1.12, processed is 1.32, total is 1.14, whilst 100g red meat gave HR 1.19, and 50g processed meat 1.51
Substituting with nuts/LF diary, wholegrain decreased this by 16-35%
2) Substriting nuts for processed meats gave HR 0.78, and red meat 0.83, and similar findings for other substitutions
Lyon heart study - follow up duration?
What outcomes?
What diets?
4 years follow up
Coronary event recurrence following MI (i.e. secondary prevention)
med diet protective vs AHA step 1 diet
Root causes analysis steps - beyond 3-5 why’s, so what and fishbone…
1) Analyse and discuss - what causes of main cause?
2) Research and interview IDT/patients, do process maps
3) Decide to address a few causes with PDSA cycles
Prescription for health
What is it?
Who did it?
Main findings or outcomes?
- Study with 49 practices, looked at 4 behaviours (PI, tobacco, smoking, diet)
- RWJF, AHRQ
4 findings:
1) Primary care is willing and able
2) Substantial practice redevelopment - patient-centred medical home
3) toolkit for health (defunct) and now ePSS
4) lots of studies
Chronic care models:
How many?
Name them…
Key principles
4 models
The chronic care model - MacColl institute and Ed Wagner - focusses on an activated patient and a proactive medical team, working with the community
The Innovative Care for Chronic Conditions - WHO - considers macro, meso and micro level care
Value based care
Chronic care manager model - AHRQ - patient centred care surrounded by IDT
Ed Wagners model…
Name it:
Key aspects?
The Chronic Care Model - MacColl institute and Ed Wagner
Community resources - co-ordinated and linked
Self-management - informed and activated patient
IT - decision support, integrated guidelines, reminder
Working under local and wider healthcare system
All together - productive relationships and better care
Group visits
What outcomes are improved?
1) Patient adherence
2) Peer support
3) Accessibility
4) Patient and provider satisfaction
5) Lower hospitalisation
What should the aims of an IDT be?
8
1) Advocate for LM
2) Utilise eMR and tech
3) Support self-efficacy
4) Optimise patient time/support/counselling
5) Utilise group visits
6) Utilise patient registries
7) Attain adherence
8) Implement good office workflows
Diseases of sleep
BIISS
Narcolepsy
Insomnia 3+, 6 months
Restless legs
Obstrutive sleep apnoea:
Prevalence, how many not diagnosed?
What is a positive STOP screening score?
Diagnostic test and cut off values?
Prevalence 26%
Undiagnosed 80%
STOP 2+ is high risk
Diagnosis based on sleep polysomnography - AHI/apnoea hypopnea index - <5 none, 5-15 mild, 15-30 mod, 30+ severe