further more extras Flashcards
How many have a smoking related disease?
16 million
whilst 17 million have AUD
Smoking causes how many deaths per year?
480,000
around 1/5th of deaths
The most effective smoking counselling includes 2 aspects:
practical - CBT/problem solving
social support
MODA of varencycline and bupropion
V is a nicotinic receptor partial agonist
B is a NA and DA re-uptake inhibitor
Smoking drug effectiveness:
Monotherapies
V 51% and 35% at 12w and 6m
B 40% at 8w
P45% at 8w
L 40% at 8w
Smoking drug combos effectiveness
V+B 71% and 58% at 12w and 6m
B + P + L 54% at 8W
B + L 50% at 8w
Smoking drugs in psychiatric disease or chronic disease
B + P + another NRT recommended
62% and 35% at 8w and 6m vs 37% and 19% with patch alone
Pregnancy and smoking
- what is best
what is what category?
counseling best
OTC no harm expected
B or V - category C
Rx NRT cat D - potential birth defects
Adolescents and NRT
it is safe, but little research on quitters
Alternative to 5As?
Ask
advise
Refer
Smoking stats
How many have AUD?
PErcentages?
17 million
30% - 26/3/1
Alcohol causes what harms (include %s) in the US?
How many attributable deaths and years of life lost?
10% of cancerns
20% intentional injuries
7% of deaths - include CTA, cancer, suicide
88000 attributable deaths, 2.5million years of life lost
4 things heavy drinking increases risk of
high BP, cancer, unintentional injuries, stroke
What % of AUD patients receive advice/tx?
10%
Heavy alcohol use definition?
5 binges in the last month
Common symptoms of AUD?
Impairment or distress Impaired control Cravings Cut down unsuccessful Internal consequences
(ICICICIC)
10% develop serious external consequences and the most severe 10% are over-represented in rehabs, jails and hospitals
And only 10% get help
17 million have AUD
12 month prevalene of AUD
mild - 10/5 male female
mod-severe - 6/2
Audit - C - what is positive?
scores of more than 5 are positive
At-risk and mild drinkers
2 signs or symptoms
3 Primary risks
4 interventions
5+ drinks monthly, 0-3 DSM criteria
primary risks AUD/liver disease/marital problems
naltrexone
brief advice
follow up booster
behavioural intervention
mild to moderated AUD
4 symptoms of impaired control
What is it similar to?
3 treatments
going over limits
wanting to cut down
internal consequences
tolerance
simlar to functional depression
treat by PCP
Behavioural health intervention
use ARMs - same effectiveness as SSRIs
severe recurrent AUD
ARMS - 4 considerations
lifestyle intervention difficult
meds equivalent to AA and counseling
as good as SSRIs
improve propotion entering recovery
Drinkings - ARMS
Naltrexon - u-opiod - 25-50mg at time of drinking
83% reduction in heavy 4% in all
Acamprosate - glutamate alterer - 11 extra days abstinence, NNT 9 and RR 0.86 for any drinking