Nutri-epi-genetics

Question 1

Hypermethylation can result in the inhibition of specific gene expression related to the inactivation of tumor ______________ while hypomethylation can result in the expression of genes that result in the activation of ____________

Answer 1

suppressors
oncogenes

Question 2

A single nucleotide polymorphism is when there is an _________ match in the nucleotide matching. It can occur through insertion and ___________

Answer 2

irregular
deletion

Question 3

Salt intake sensitivity of BP is __________ risk factor for cardiovascular morbidity. Up to ___% with hypertension are salt sensitive

Answer 3

Independent
50

Question 4

The two primary genes associated with salt sensitivity include renin-angiotension ______________ _____ and ____________ gene

Answer 4

converting enzyme gene
angotensin

Question 5

The INS/DEL polymorphoism that occurs in the allele of the ACE gene has been associated with _______ _________ hypertension

Answer 5

salt sensitive

Question 6

People with the TCFL2 variation experience a beneficial effect of ____________ intake on diabetes risks

Answer 6

whole grain

Question 7

Main methyl donors include (my friends can break vs) as they contribute as ____ and contribute to DNA methylation
-Methionine
-__________
-Choline
-_____
Vitamin B_______ _________ __________

Answer 7

Precursors

folate
betaine
b2, 6, 12

Question 8

DNA methylation and cancer is seen when ___ deficiency can modify the methylation status of carcinogenetic genes. found in leafy greens, beans)

Answer 8

folate

Question 9

________ is sulfur containing AA (obtained from egg, fish, soy, dairy)

Answer 9

methionine

Question 10

Apoe4 and apoe3 are associated with alzheimer disease as they impact ___________ metabolism

Answer 10

fat

Question 11

DOHaD is the developmental orgin of health and disease and amins to understand _______ and risk of __________

Answer 11

ancestry
chronic disease

Question 12

High fat during pregnancy increased risk for _____________ such as increased _______ and impaired insulin and glucose tolerance

Answer 12

metabolic syndrome
adiposity

Question 13

Theory of early programming assummed excessive dietary intake during pregancy may deteriorate functionality of __________ infundibula nucleus

Answer 13

hypothalamus

Question 14

On high fat diet, offspring with fetal undernutrition exhibited leptin (inhibition of hunger) _________ compared to control

Answer 14

surge

Question 15

Dutch famine offspring (6 generations later) exhibited less _________________ of the IGF2 gene and SIRT1 gene which increases risk of _________________

Answer 15

DNA methylation
metabolic syndrome