Nut Wk6 - Asthma Flashcards
What is the most common lung disease
Asthma
What is a hygiene hypothesis for asthma
exposure to microbial products early in life may protect against asthma later
What are the activities/potential mechanisms of effect of carotenoids, Vitamin C and E
Antioxidants for protection against endogenous and exogenous oxidant inflammation
What are the activity.potential mechanisms of effect of Vitamin C?
Prostagladin inhibition
What are the activity.potential mechanisms of effect of Vitamin D?
Modulation of T-cell responses
What are the activity.potential mechanisms of effect of Vitamin E?
Membrane stabilization; inhibition of IgE production
What are the activity.potential mechanisms of effect of Flavones, flavonoids?
Antioxidants; mast cell stabilization
What are the activity.potential mechanisms of effect of Magnesium?
Smooth muscle relaxation; mast cell stabilization
What are the activity.potential mechanisms of effect of Selenium?
antioxidant cofactor in glutathione peroxidase
What are the activity.potential mechanisms of effect of Copper and Zinc?
Antioxidant cofactors in superoxide dismutase; Zinc modulates T-cell responses
What are the activity.potential mechanisms of effect of Omega-3 fatty acids?
Leukotriene substitution, stabilization of inflammatory cell membranes. PUFAs modulate T-cell response
What are the activity.potential mechanisms of effect of Omega-6 PUFAs, trans fatty acids
increased eicosanoid production; increased inflammation and worsening respiratory function
What are the activity.potential mechanisms of effect of Sodium?
increased smooth muscle contraction; reduced intake may increase airway responsiveness
What does dietary methylanthines do?
Caffeine can relax smooth muscles and open airways
what are examples of dietary methylxanthines
caffeine (coffee) and theobromine
what is in cocoa that is a methylxanthines and help reduce coughing?
theobromine
what is salicylate-free diet helpful for?
only helpful for those who have a medically documented reaction to salicylates
Approximately 5-10% of people with asthma have ?
a sulphite sensitivity
what are symptoms of sulphite sensitivity?
- flushing
- tachycardia
- wheezing
- hives
- dizziness
- upset stomach
- diarrhea
- tingling
- difficulty swallowing
- fainting
what are the dietary sources of sulphite?
- dried fruit
- bottled citrus juices
- wine
- molasses
- fermented foods
IgG-antigen complexes activate what?
the complement pathway and release inflammatory mediators
IgG-antigen complexes are typically cleared by ?, but in the presence of excess antigen, clearing capacity may be ? resulting in the excess being deposited in ?
macorphages
saturated
tissues
Deposition of IgG-antigen complexes in tissues causes?
inflammation and tissue damage
what’s the difference between IgG food reactions and IgE food allergies
IgE food allergies are immediate reactions that occur within minutes or hours of consuming food and may include serious reactions
IgG food sensitivity is a delayed reaction that occurs hours to days after the food is consumed, with symptoms that may not appear for days or months
