Numbers: IL, IFN, LT, CD, Complement Flashcards
Major chemotactic factor for neutrophils
IL-8
LTE4
C5a
IL-6
Secreted by macrophages
Causes fever and stimulates acute phase reactions
HLA subtype associated with celiac
DQ2
DQ8
IL-10
Inhibitory/modulatory
Secreted by Th2, and regulatory T cells
Il-1
AKA osteoclast activating factor
Fever, inflammation
Causes endothelium to express adhesion molecules
Induces chemokine secretion to recruit WBCs
Complement proteins causing anaphylaxis
C3a, C4a, C5a
Decay-accelerating factor is AKA
CD55
B27 associated with
Psoriatic arthritis
Ankylosing spondylitis
IBD arthritis
Reactive arthritis (Reiter syndrome)
Receptor for EBV
CD21 on B cells
Expresses CD4, CD25
Regulatory T cells
CD16
NK cells, binds
Enhances activity of NK cells
IL-2
IL-12
IFN-a
IFN-B
HLA subtype associated with Rheumatoid Arthritis
DR4
4 walls in a rheum
Glycoproteins synthesized by virus-infected cells that prime nearby cells for defense
IFN-a
IFN-b
CD56
NK cells
Regulatory T cells identified by expression of
CD3 - all T cells
CD4 - all Th cells
CD25, FOXP3
Antibody-dependent cell-mediated cytotoxicity involves binding of what
CD16 (NK) on Fc region of a bound Ig
IL-12
Secreted by macrophages
Activates NKC
Th0–>Th1 differentiation
Mediates septic shock
Causes cachexia in malignancy
TNF-a
CD34
hematopoetic stem cells
HLA subtype associated with Hashimoto’s
DR3
DR5
Complement protein for opsonization
C3b
CD14, CD40
MHCII, B7
Macrophages
HLA subtype associated with Goodpasture syndrome
DR2
Expresses CD4, CD40L
Th
Langerhans histiocytes express what markers
CD1a
S-100
HLA subtype associated with hemachromatosis
A3
IFN-gamma
Secreted by NK cells and Th1 cells
Activates macrophages
HLA subtype associated with DM type 1
DR3
DR4
IL-4 vs IL-5
IL-4 stimulates IgE and IgG switching
IL-5 stimulates IgA switching and eosinophils
