Autoantibodies

Question 1

Rheumatoid arthritis

Answer 1

Anti IgG (Rheumatoid factor)
Anti-citrullinated protein Ab (ACPA) (more spec)

Question 2

CREST scleroderma

Answer 2

Anti-centromere

Question 3

Diffuse scleroderma

Answer 3

Anti-Scl-70 (anti-DNA topoisomerase)

Question 4

Drug-induced lupus

Answer 4

Anti-histone (seen in 50% SLE)

Question 5

SLE

Answer 5

Anti-nuclear (ANA)
Anti-Smith (high spec, low sens)
Anti-dsDNA

Question 6

Lupus nephritis

Answer 6

Anti-dsDNA

Question 7

Polymyositis/dermatomyositis

Answer 7

Anti-Jo-1

Question 8

Sjogren

Answer 8

Anti-SSA (Ro)

Anti-SSB (La)

Question 9

MCTD

Answer 9

Anti-U1-RNP (ribonucleoprotein)

Question 10

Pemphigus vulgaris

Answer 10

Anti-desmoglein

Question 11

Myasthenia gravis

Answer 11

Anti-AchR

Question 12

Celiac

Answer 12

Anti-endomysial (anti-tissue transglutaminase)

Anti-gliadin

Question 13

Primary biliary cirrhosis

Answer 13

Anti-mitochondrial

Question 14

Autoimmune hepatitis

Answer 14

Anti-smooth muscle

Question 15

Type 1 DM

Answer 15

Anti-glutamate decarboxylase

Question 16

Graves

Answer 16

Anti-thyrotropin receptor (bind and stimulate)

Question 17

Hashimoto

Answer 17

Anti-TPO

Question 18

Anti-thyroglobulin

Answer 18

Seen in Hashimoto or Graves

Question 19

Goodpasture

Answer 19

Anti-basement membrane

Question 20

c-ANCA

Answer 20

Granulomatosis with polyangiitis (Wegener’s)

Question 21

p-ANCA

Answer 21

Churg-Strauss
Microscopic polyangiitis
Pauci-immune crescenteric glomerulonephritis