Nucleotides + Nuclei Acids Flashcards
Nucleotides
DNA aNd RNA are polymers that are made up of from several nucleotides
Each nucleotide has a :
Nitrogenous base
Pentose Sugar
Phosphate group
DNA
The components of DNA include a deoxyribose sugar with a. 2’ hydrogen position
A phosphate group
Double helix, which is a three dimensional shape , twisting of the molecule
4 nitrogenous bases : A C T G
RNA
A ribose sugar with a hydroxyl at a 2’ position
A phosphate group
4 bases: U A C G
Different from dna as dna has a oh at 2’ position
The hydroxyl in rna makes it more susceptible for hydrolysis
Purines and pyramidines
Two structural formats
Adenine + Guanine = purines which means rhat they have a double ring structure
While uracil, thymine and cytosine = pyramidines which means that they have a single ring structure
DNA compared to RNA
Dna:
Deoxyribose sugar
Based = A T C G
Double stranded helix
RNA:
Ribose
bases= U A C G
single strand
Phosphodiester bonds
Condensation between two nucleotides forms a phosphodiester bond
PhosphoDI(ester) = contains two ester bonds + phosphate group
Synthesis of polynucleotides requires formation of phosphodiester bonds
Breakage of polynucleotides requires breakage of phosphodiesyer bonds
Energy
All organisms require energy for
Anabolic reactions = larger molecules being formed from smaller molecules
Moving substances across the cell or membrane
In animals its required for muscle contraction
ATP used to transfer energy thats why its named as an energy currency
ATP
Type of nucleic acid that is an energy carrying molecule
Adenosine can be combined with diff phosphates:
Adenosine monophosphate AMP
Adenosine disphosphate. ADP
Adenosine triphosphate. ATP
DNA STRUCTURE
Made up of two polynucletides that are lying side by side opposite to each other = antiparralell
Alternating deoxyribose sugars that are bonded together to form a sugar phosphate backbone
These bonds are called phosphodiester bonds
Phosphodiester bond links the 5 carbon to another molecule of another phosphate group that also contains a phosphodiester bond attached to its 3 carbon
DNA hydrogen bonding
DNA held together by hydrogen bonding between its bases
Hydrogen pairing always happens between the same bases, this is called complementary bases