Nuclear Receptors Flashcards
What does GR stand for?
glucocorticoids
What does PR stand for?
progesterone
What does AR stand for?
androgen
What does ER stand for?
oestrogen
What does MR stand for?
mineralcorticoids
NR?
NUCLEAR RECEPTOR
HOMODIMERS?
GR, PR, AR, ER,MR
HETERODIMERS? (with RXR-retinoid receptor x)
TR, RAR, VDR, PPAR
What does TR stand for?
thyroid
What does RAR stand for?
retinoid
What does VDR stand for?
vitamin D
What does PPAR stand for?
peroxisome proliferator
For Class I nuclear receptors, what is their mechanism of action?
Bind their ligand in the cytoplasm
Form homodimers
Most members of subfamily 3 (e.g. AR, ER, GR, PR)
What is the mechanism of action for Class II nuclear receptors?
Reside in the nucleus independently from their binding status
Form heterodimers (with RXR)
Bind co-repressors and co-activators
Most members of subfamily 1 (e.g. RAR, RXR, TR)
Autologous?
The concentration of the receptor can increase or decrease upon their activation
Heterologous?
The concentration of the receptor can increase or decrease upon the activation of other nuclear receptors
what can progesterone regulate?
lactation
What is the clinical relevance of nuclear receptors?
They can compensate a hormonal deficit
Compensate excessive hormonal secretion
Modify the function of endocrine signal
Treatment of non-endocrine disease blocking endocrine signal
What are the physiological activities of oestrogen?
Development and maintenance of female sexual organs and secondary sex-characteristics
Affect the release of pituitary hormones, affecting lactation, ovulation androgen and other hormone secretion
Have effects on the skeletal system (e.g. calcium deposition, bone formation and epiphyseal-closure)
Possible side effect of incurin to do with bone marrow?
bone marrow function suppression
possible uses of incurin in vet med?
increase uterus tone in spayed females
prevent pregnancy-not recommended
treatment of prostate hypertrophy
