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STRUC+FUNC 1 (vet) > Nuclear Receptors > Flashcards

Nuclear Receptors Flashcards

1
Q

What does GR stand for?

A

glucocorticoids

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2
Q

What does PR stand for?

A

progesterone

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3
Q

What does AR stand for?

A

androgen

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4
Q

What does ER stand for?

A

oestrogen

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5
Q

What does MR stand for?

A

mineralcorticoids

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6
Q

NR?

A

NUCLEAR RECEPTOR

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7
Q

HOMODIMERS?

A

GR, PR, AR, ER,MR

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8
Q

HETERODIMERS? (with RXR-retinoid receptor x)

A

TR, RAR, VDR, PPAR

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9
Q

What does TR stand for?

A

thyroid

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10
Q

What does RAR stand for?

A

retinoid

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11
Q

What does VDR stand for?

A

vitamin D

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12
Q

What does PPAR stand for?

A

peroxisome proliferator

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13
Q

For Class I nuclear receptors, what is their mechanism of action?

A

Bind their ligand in the cytoplasm
Form homodimers
Most members of subfamily 3 (e.g. AR, ER, GR, PR)

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14
Q

What is the mechanism of action for Class II nuclear receptors?

A

Reside in the nucleus independently from their binding status
Form heterodimers (with RXR)
Bind co-repressors and co-activators
Most members of subfamily 1 (e.g. RAR, RXR, TR)

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15
Q

Autologous?

A

The concentration of the receptor can increase or decrease upon their activation

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16
Q

Heterologous?

A

The concentration of the receptor can increase or decrease upon the activation of other nuclear receptors

17
Q

what can progesterone regulate?

A

lactation

18
Q

What is the clinical relevance of nuclear receptors?

A

They can compensate a hormonal deficit
Compensate excessive hormonal secretion
Modify the function of endocrine signal
Treatment of non-endocrine disease blocking endocrine signal

19
Q

What are the physiological activities of oestrogen?

A

Development and maintenance of female sexual organs and secondary sex-characteristics
Affect the release of pituitary hormones, affecting lactation, ovulation androgen and other hormone secretion
Have effects on the skeletal system (e.g. calcium deposition, bone formation and epiphyseal-closure)

20
Q

Possible side effect of incurin to do with bone marrow?

A

bone marrow function suppression

21
Q

possible uses of incurin in vet med?

A

increase uterus tone in spayed females
prevent pregnancy-not recommended
treatment of prostate hypertrophy

STRUC+FUNC 1 (vet) (24 decks)

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