Mechanisms of Cell Deviance Flashcards
what type of disease is cancer?
it is a genetic disease
what happens if you removed 2/5 liver lobes of a rat?
it will regenerate in 5-7 days
what can zebra fish regenerate?
their heart
what are the efficient mechanisms that prevent mutation?
cell cycle control
proof reading mechanisms
genetic code
what are the 10 hallmarks of cancer?
avoiding immune destruction
evading growth suppressors
enable replicative immortality
tumour-promoting inflammation
activating invasion and metastasis
genomic instability
inducing angiogenesis
resisting cell death
deregulating cellular energetics
sustaining proliferative signaling
what is neoplasia?
literally new growth - refers to neoplasms/tumours
what is a neoplasm?
any tumour where growth is uncontrolled
what is a tumour?
swelling
what is oncology?
from oncos - greek for swelling to describe tumours
benign?
usually slow growing and do not metastasise
malignant?
having features of invasiveness, metastaiss and anaplasia
anaplasia?
lots of differentiation becoming a more primitive cell type
cancer?
a malignant neoplasm
what is cell senesce?
when they lose their ability to proliferate
what are the reactive oxygen species?
O2-, H2O2, HO*
(oxide ion, hydrogen peroxide and hydroxide free radical)
