NTD

Question 1

why do u get NTD? different types?

Answer 1

• Result from failure of the neutral tube to close

• Failure can occur caudally or cranially
• Cranial defect results in anencephaly
• Caudal defect results in spina bifida

Question 2

Anencephaly

Answer 2

failure of neural tube to close cranially

Absence of cranial structures, including brain

Incompatible with life!!!!!!

Question 3

Rachischisis

Answer 3

Failure of neural fold elevation, neural tube does not form at ALL! so theres no formation of the neuroectoderm!

(somtimes known as complete spina bifida) refers to a severe form of spina bifida where there is a cleft through the entire spine.

Question 4

neural tube defect is an OPEN defect, what can this mean?

Answer 4

embrynic protein can leak into amniotic fluid and into circulation

Question 5

NTD: diagnosis & prevention & causes

Answer 5

measure for maternal serum a-fetoprotein

ultrasound

Causes: environmental, genetic, diet

give them FOLIC ACID!

(Folic acid pre-conceptually (3 mo) and for the 1st trimester reduces incidence by 70% )

Question 6

what is the best known factor influencing NTD risk?

Answer 6

diminished folate

Question 7

Question 8

what baby defect is also associated with folate deficiency ?

Answer 8

Cleft palate is also associated with folate deficiency. During baby checks, always make sure the baby is feeding normally and examine the palate for defects