NSAIDs

Question 1

Celecoxib

Answer 1

1. Selective COX -2 inhibitor
2. Reversible
3. Treatment of A) RA
   B) osteoarthritis
   C) acute mild to moderate pain
4. Oral , once or twice daily, h.l 11 h , p450 , urine and feces

Question 2

Acetaminophen

Answer 2

1. Inhibits PG synthesis in the CNS
2. Antipyretic and analgesic
3. Less effect on the COX in peripheral t ( weak I )
4. مهم خافض حرارة و مسكن للالم عند الاطفال المصابين بال chickenpox due to (the risk of raye syndrome with aspirin)

Question 3

Inhibitions of COX-1

Answer 3

Prevention of CV events

Question 4

Aspirin at high doses:

Answer 4

Exhibits Anti inflammatory activity

Question 5

Aspirin at lower doses:

Answer 5

1. Prevention of cardiovascular events such as stroke and myocardial infarction
2. Analgesic activity

Question 6

Aspirin

Answer 6

1. Bind irreversible
2. Inhibit platalet aggregation
3. Is used acutely to reduce the risk of death in acute MI and in patients undergoing revascularization procedure

Question 7

Analgesic action

Answer 7

1. Inflammation ➡️histamine and pradykinin ➡️PGE2 ➡️ sensitize nerve ending (⬇️PGE2 >⬇️pain )
2. ⬇️COX-2 ⬇️pain

Used for mild to moderate pain

Question 8

Ketorolac

Answer 8

Can be used for severe pain but shot duration

Question 9

Antipyretic action

Answer 9

Inflammation ➡️WBCs➡️cytokines ➡️PGE2 ➡️fever

❌PGE2:❌fever

Question 10

Inflammations that can be treated by NSAIDs

Answer 10

1. Osteoarthritis
2. Gout
3. Rheumatoid arthritis

Question 11

Combination of opioids and NSAIDs is used for?

Answer 11

Treating pain caused by malignancy

Question 12

NSAlDs that can be used for antipyretic activity

Answer 12

1. Aspirin
2. Ibuprofen
3. Naproxen

Question 13

Raye syndrome

Answer 13

A syndrome that can cause fulminating hepatitis with cerebral edema,often leading to death

Question 14

How to treat chickenpox

Answer 14

Aspirin should be avoided ❌❌❌ in patients less than 20 years old with chickenpox or influenza
2. Acetaminophen ✅✅✅is the analgesic/ antipyretic of choice for children with chickenpox

Question 15

Methyl salicylate

Answer 15

Is used as cutaneous counterirritant such arthritis cream and sports rubs

Question 16

Pharmacokinetics of aspirin

Answer 16

1. Oral
2. Passive absorbed
3. ✔️BBB , placenta and skin
4. Met liver
5. Elimination first and second order by kidney
   ما لازم بتاخد مع اسد ثاني لانه بحبسه