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Pharma 2020 > Antibiotics > Flashcards

Antibiotics Flashcards

1
Q

Isoniazid

A
  • narrow spectrum antibiotics

* active only against T. B

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2
Q

Broad spectrum antibiotic

A

Tetracycline

  1. Fluoroquinlones
  2. Carbapenems
  3. chloramphenicol
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3
Q

Antibiotics that are poorly absorbed from G. I. T

A

Vancomycin

  1. Amino glycosides
  2. Amphotericin B
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4
Q

Antibiotics that show synergism

A

B-lactams and Aminoglycoside

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5
Q

Natural penicillins

A

Penicillin G

Penicillin V

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6
Q

Semisynthetic penicillins

A
  1. Amoxicillin

2. Ampicillin

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7
Q

Penicillin V and penicillins G similarities and differences

A

Similarities:
- Natural penicillins
- similar spectrum
Differences:
- penicillin V is more acid stable than penicillin G
- penicillin V could be given orally, but penicillin G is not

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8
Q

Penicillin remains the drug of choice for?

A
  1. Gas gangrene ( C. Perfringens )

2. Syphilis ( Treponema pallidum )

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9
Q

Anti staphylococcal penicillins

A
  1. Methicillin
  2. Nafcillin
  3. Oxacillin
  4. Dicloxacillin
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10
Q

Anti staphylococcal penicillins

A
  1. Penicillinase resistant penicillins
  2. Have minimal to no activity against gram negative
  3. They are used for treatment of MSSA
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11
Q

Methicillin

A
  1. Anti staphylococcal penicillin
  2. Is not used clinically
  3. It is used in lab tests MRSA
  4. Cause interstitial nephritis
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12
Q

MRSA

A

Hospital acquired infections

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13
Q

Extended- spectrum penicillins

A
  1. Ampicillin

2. Amoxicillin

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14
Q

Amoxicillin and ampicillin

A
  1. Similar spectrum of penicillin ➕➕ gram negative bacilli
  2. Treatment of Respiratory infections
  3. Extended- spectrum penicillins
  4. Semi synthetic
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15
Q

Amoxicillin

A
  1. Extended- spectrum penicillins
  2. Used as prophylactically by dentists 🦷 for prevention of bacterial endocarditis
  3. Amoxicillin +clavulanic acid = drug resistance to B lactamase I
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16
Q

Antipseudomonal penicillins

A
  1. Piperacillin (the most potent) , used with tazobactam

2. Ticarcillin

17
Q

Antipseudomonal penicillins (spectrum) or pibaracillin and ticarcillin spectrum

A
  1. Pseudomonas aeruginosa

2. Gram negative bacilli

18
Q

How to treat gram negative bacilli

A
  1. Amoxicillin
  2. Ampicillin
  3. Piperacillin
  4. Ticarcillin
19
Q

Clavulanic acid is used with

A
  1. Ticarcillin

2. Amoxicillin

20
Q

Klebsiella

A

Could not be treated by piperacillin and ticarcillin

21
Q

Depot from

A

Penicillin G

Pharma 2020 (9 decks)

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