Antibiotics 2

Question 1

Carbapenems / carbapenems drug

Answer 1

1. Broad spectrum antibiotic
2. Synthetic B- lactam antibiotics
   ( Amipenem, meropenem , dori, Ertapenem )
3. Cell wall inhibitor

Question 2

Imipenem

Answer 2

1. Synthetic B-lactam
2. It is used in empiric therapy
3. Spectrum: gram negative and positive , anaerobes and p. Aeruginosa
4. ما بتكسر بالبيتا لاكتاميز
5. It is compounded with cilastatin
6. IV
7. Nephrotoxic

Question 3

Monobactams مهم

Answer 3

1. Cell wall inhibitors
2. The beta lactam ring are not fused عشان هيك اسمه mono
3. Aztreonam

Question 4

Aztreonam

Answer 4

1. Monolactam cell wall inhibitors
2. Spectrum: gram negative
3. مقاوم لل بيتا لاكتاميز
4. IV or IM
5. امن لذلك هو بديل اذا المريض عنده حساسية

Question 5

Clavulanic acid

Answer 5

B lactam inhibitors
2- amoxicillin
3. Ticarcillin

Question 6

Sulbactam

Answer 6

B lactam inhibitors

➡️ ampicillin

Question 7

Tazobactam

Answer 7

B lactam inhibitors

➡️ piperacillin

Question 8

Vancomycin

Answer 8

Cell wall inhibitors 
It is used to treat 1) life threatening infections 
2) MRSA
3) MRSE 
4) enterococcal infections

Question 9

P. aeruginosa

Answer 9

Imipenem
Piperacillin
Ticarcillin
Fourth generation cefepime

Question 10

Enterococcal infections

Answer 10

Vancomycin
Combination of B lactam and aminoglycosides
❌ cephalosporins

Question 11

Cephalosporins are ineffective against

Answer 11

1. MRSA
2. L. Monocytogens
3. C. Difficile
4. Enterococci

Question 12

First generation

Answer 12

1. Act as penicillin G
2. Spectrum :
   ✅ MSSA
   ✅ proteus
   ✅ E. Coli
   ✅ k. Pneumonia
   يعني بتشتغل على +و هدول من ال -

Question 13

Cefotetan

Answer 13

1. 2nd generation cephalosporins

2. Act on (g - )anaerobes :- bacteroid fragility’s

Question 14

Second generation

Answer 14

• gram positive is weaker

3 additional gram negative

Question 15

Cefoxitin

Answer 15

1. Act on gram negative anaerobes ( bacteroids fragilis )

* Second generation

Question 16

Ceftriaxone and cefotaxime

Answer 16

Third generation
meningitis ✅
Excretion through the bile into feces
4. Treatment of neonatal and childhood meningitis caused by H. Influenza

Question 17

Collateral damage

Answer 17

Third generation of cephalosporins

2. Fluoroquinolone

Question 18

Cefepime

Answer 18

1. Aerobic gram negative
2. P. Aeruginosa 📌📌
3. Streptococci and staphylococci ( MSSA)
4. Should be given parenterally

Question 19

Ceftaroline

Answer 19

1. MRSA ( PBP2a )
2. Pneumonia يلي من المستشفى (PBP2x)
3. Skin
4. Gram negative and gram positive

Question 20

Cefazolin

Answer 20

First generation
Short half life
Prophylaxis dose prior to surgery
Penetration bone 🦴 🦴🦴🦴عشان هيك بنستخدمه بعمليات العظام

Question 21

Tetracycline

Answer 21

1. 30 S

2. في حال اخذناهم مع اكل في درات ثنائية او تلاثية رح يقل الامتصاص