Lec 20 Flashcards
Sumatriptan
- 5HT1
- Treating acute attacks of migraine
- Contraindicated with ischemic heart disease,angina and hypertension , it may coronary vasoconstriction
- Serotonin agonist
- Relieves the nausea and vomiting عن طريق 5HT3
- Oral and subcutaneous
Buspirone
- Serotonin agonist
2. Anxiolytics
Methysergide
- Serotonin antagonist
- Blocks 5HT on S. M and V. C
- Prophylactic agent for mirainous headache
Cyproheptadine
- Antihistamines
- Serotonin antagonist
- Increase the Appetite
- Blocks 5HT
- Relive the itching
Ondansetron
- Serotonin antagonist
- Blocks 5HT-3
- Managment nausea and vomiting
Prochlorperazine and haloperidol
Serotonin antagonist
Anti 5HT
Used for resistant migraine acute attack
Therapeutic used of prostaglandins
- Pain
- Inflammation
- Fever
- G. I. T : mucus production and acid secretion
- Uterine contraction
- Renal blood flow
PGE1 is produced in
- Seminal vesicles
- Cavernous t
- Placenta
- The ductus arteriosus of the fetus مهم
Therapeutic use of alprostadil
- Erectile dysfunction
2. Keep the ductus arteriosus open
Lubiprostone
- PGE1 analogue
2. Treatment of constipation . HOW ??????? ⬆️⬆️ intestinal fluid secretion
Misoprostol
- PGE 1
- ⬆️⬆️ mucus and bicarbonate production
- ⬇️⬇️ gastric acid secretion زي السيراتونين و الH2 blocker
1+2=protect the mucosal lining - Out of label 🏷 for labor induction
- There’s a combination containing misoprostol and diclofenac
- Contraindicated during pregnancy 🤰
Drugs analogue to PGE2
- Alprostadil
- Lubiprostone
- Misoprostol
PGF2a analogs ?
- Bimatoprost
- Latanoprost
- Tafluprost
- Travoprost
PGF2a indicated for the treatment of
Open-angle glaucoma, they ⬆️⬆️uveoscleral outflow and ↓↓ intraocular \ pressure.
PGI2 analogs
Epoprostenol
- Iloprost
- Treprostinil
Epoprostenol , treprostinil and iloprost
Pulmonary vasodilators that are used for the treatment of pulmonary arterial hypertension
Naproxen 📌📌📌📌📌📌
For patients with CV disease in whom NSAIDs treatment cannot be avoided
و يستخدم خافض حرارة
5-HT2C receptors in the CNS may cause
reduction in appetite,
5-HT3 receptors location
GI tract and vomiting center
5-HT3 receptors action
emesis
serotonin Therapeutic Uses
depression
migraine headache
obesity
effective therapies for depression
selective serotonin reuptake inhibitors SSRIs) serotonin and norepinephrine reuptake inhibitors (SNRIs)
Serotonin Agonists
Sumatriptan
Buspirone
thromboxane A2 (TXA2) function and released from
platelets
aggregation
v.c
PGI 2
endothelial cells
inhibiting platelet aggregation
producing vasodilation
Alprosradil
PGE1
Bimatoprost
- Treatment of eyelash hypotrichosis
Bimatoprost, latanoprost, tafluprost, and travoprost are
ophthalmic solutions once a day and
are as effective as timolol or better in reducing intraocular
pressur
Bimatoprost increases
eyelash prominence, length, and darkness
Prostaglandin F2α analogs
blurred vision, iris color change (increased
brown pigmentation), increased number and pigment of eyelashes,
ocular irritation, and foreign body sensation.
iloprost administered
Inhaled
Epoprostenol and treprostinil
are administered as a
continuous intravenous infusion, and treprostinil may also be administered orally or via inhalation or subcutaneous infusion.
