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Pharma 2020 > Lec 20 > Flashcards

Lec 20 Flashcards

1
Q

Sumatriptan

A
  1. 5HT1
  2. Treating acute attacks of migraine
  3. Contraindicated with ischemic heart disease,angina and hypertension , it may coronary vasoconstriction
  4. Serotonin agonist
  5. Relieves the nausea and vomiting عن طريق 5HT3
  6. Oral and subcutaneous
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2
Q

Buspirone

A
  1. Serotonin agonist

2. Anxiolytics

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3
Q

Methysergide

A
  1. Serotonin antagonist
  2. Blocks 5HT on S. M and V. C
  3. Prophylactic agent for mirainous headache
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4
Q

Cyproheptadine

A
  1. Antihistamines
  2. Serotonin antagonist
  3. Increase the Appetite
  4. Blocks 5HT
  5. Relive the itching
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5
Q

Ondansetron

A
  1. Serotonin antagonist
  2. Blocks 5HT-3
  3. Managment nausea and vomiting
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6
Q

Prochlorperazine and haloperidol

A

Serotonin antagonist
Anti 5HT
Used for resistant migraine acute attack

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7
Q

Therapeutic used of prostaglandins

A
  1. Pain
  2. Inflammation
  3. Fever
  4. G. I. T : mucus production and acid secretion
  5. Uterine contraction
  6. Renal blood flow
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8
Q

PGE1 is produced in

A
  1. Seminal vesicles
  2. Cavernous t
  3. Placenta
  4. The ductus arteriosus of the fetus مهم
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9
Q

Therapeutic use of alprostadil

A
  1. Erectile dysfunction

2. Keep the ductus arteriosus open

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10
Q

Lubiprostone

A
  1. PGE1 analogue

2. Treatment of constipation . HOW ??????? ⬆️⬆️ intestinal fluid secretion

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11
Q

Misoprostol

A
  1. PGE 1
  2. ⬆️⬆️ mucus and bicarbonate production
  3. ⬇️⬇️ gastric acid secretion زي السيراتونين و الH2 blocker
    1+2=protect the mucosal lining
  4. Out of label 🏷 for labor induction
  5. There’s a combination containing misoprostol and diclofenac
  6. Contraindicated during pregnancy 🤰
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12
Q

Drugs analogue to PGE2

A
  1. Alprostadil
  2. Lubiprostone
  3. Misoprostol
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13
Q

PGF2a analogs ?

A
  1. Bimatoprost
  2. Latanoprost
  3. Tafluprost
  4. Travoprost
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14
Q

PGF2a indicated for the treatment of

A

Open-angle glaucoma, they ⬆️⬆️uveoscleral outflow and ↓↓ intraocular \ pressure.

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15
Q

PGI2 analogs

A

Epoprostenol

  1. Iloprost
  2. Treprostinil
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16
Q

Epoprostenol , treprostinil and iloprost

A

Pulmonary vasodilators that are used for the treatment of pulmonary arterial hypertension

17
Q

Naproxen 📌📌📌📌📌📌

A

For patients with CV disease in whom NSAIDs treatment cannot be avoided
و يستخدم خافض حرارة

18
Q

5-HT2C receptors in the CNS may cause

A

reduction in appetite,

19
Q

5-HT3 receptors location

A

GI tract and vomiting center

20
Q

5-HT3 receptors action

A

emesis

21
Q

serotonin Therapeutic Uses

A

depression
migraine headache
obesity

22
Q

effective therapies for depression

A

selective serotonin reuptake inhibitors SSRIs) serotonin and norepinephrine reuptake inhibitors (SNRIs)

23
Q

Serotonin Agonists

A

Sumatriptan

Buspirone

24
Q

thromboxane A2 (TXA2) function and released from

A

platelets
aggregation
v.c

25
Q

PGI 2

A

endothelial cells
inhibiting platelet aggregation
producing vasodilation

26
Q

Alprosradil

A

PGE1

27
Q

Bimatoprost

A
  1. Treatment of eyelash hypotrichosis
28
Q

Bimatoprost, latanoprost, tafluprost, and travoprost are

A

ophthalmic solutions once a day and
are as effective as timolol or better in reducing intraocular
pressur

29
Q

Bimatoprost increases

A

eyelash prominence, length, and darkness

30
Q

Prostaglandin F2α analogs

A

blurred vision, iris color change (increased
brown pigmentation), increased number and pigment of eyelashes,
ocular irritation, and foreign body sensation.

31
Q

iloprost administered

A

Inhaled

32
Q

Epoprostenol and treprostinil

are administered as a

A 
continuous intravenous 
infusion, and treprostinil may 
also be administered orally or 
via inhalation or subcutaneous 
infusion.

Pharma 2020 (9 decks)

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