Antibiotis 3

Question 1

Chloramphenicol

Answer 1

1. Protein synthesis inhibitors
2. Life threatening infections
3. Reversible binding to 50 S
4. ⬇️ protein and ATP synthesis in host cell
5. B. M toxicity
6. Drug interactions: ⬇️ hepatic function: ❌ warfarin and phenytoin
7. A.E anemia, Gray baby syndrome

Question 2

Macrolides and it’s drug

Answer 2

1. Irreversible binding to 50 S
2. Bacteriostatic , but in higher doses can be bactericidal
3. Drug: Erythromycin
   Clarithromycin
   Azithromycin
   Telithromycin
4. ❌ hepatic metabolism

Question 3

Erythromycin

Answer 3

1. Used in patients with penicillin allergy
   2: Resistance: plasmid associated erythromycin esterases in gram negative
2. Destroyed by gastric acid

Question 4

Clarithromycin

Answer 4

Helicobacter pylori

Question 5

Azithromycin

Answer 5

Respiratory infection due influenza and moraxella catarrhalis
IV
Stable in stomach acid
بقل الامتصاص في حاله الطعام

Question 6

Telithromycin (ketolides)

Answer 6

Neutralizes the most common resistance mechanisms

Question 7

Aminoglycoside

Answer 7

1. Treat aerobic gram negative
2. Bactericidel
3. Concentration dependent كلما زدت الجرعة رح يموت اكتر
4. Post antibiotics effect
5. IV
6. No cross resistance

Question 8

Aminoglycoside drugs

Answer 8

Amikacin

2. Gentamicin
3. Tobramycin
4. Streptomycin

Question 9

Amikacin

Answer 9

ما بتاثر بالانزيمات يلي بتفرزها البكتيريا

2. Aminoglycoside

Question 10

Neomycin

Answer 10

1. Aminoglycoside
2. ❌❌ parenterally ➡️nephhrotoxicity
   ✅oral ✅topical
3. In topical administration ➡️ allergic reaction

Question 11

Tetracycline

Answer 11

1. 30 S
2. بقل امتصاصهم في حال اخذناهم مع اكل في عناصر ثنائية او ثلاثية
3. Bacteriostatic
4. Gram negative and positive
5. يمنع للحامل و المرضع و الطفل

Question 12

Glycylcylines

Answer 12

1. Tigecycline , a derivative of minocycline
2. Bacteriostatic
3. Complications skin , soft tissue and intra abdominal